Integrated System for Bacterial Detection and Biofilm Treatment on Indwelling Urinary Catheters
Integrated System for Bacterial Detection and Biofilm Treatment on Indwelling Urinary Catheters
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DOI：
10.1109/tbme.2021.3066995
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发表时间：
2021-11-01
影响因子：
4.6
通讯作者：
Ghodssi, Reza
中科院分区：
文献类型：
--
作者：
Huiszoon, Ryan C.;Han, Jinjing;Ghodssi, Reza
目标：这项工作介绍了一个集成的系统与商业弗利导尿管无缝结合的细菌生长传感和生物膜治疗。研究方法：该系统由柔性叉指电极组成，通过3D打印插入物与导尿管结合，用于阻抗感测和基于生物电效应的治疗。每个功能都使用定制应用程序进行无线控制，该应用程序提供了一个用户友好的界面，用于通过蓝牙与定制PCB进行通信，以促进实践中的实施。结果如下：集成导管系统保持了留置导管的主要功能-尿液引流、球囊充气-同时能够检测大肠杆菌的生长，在新开发的模拟膀胱环境中测试，24小时后阻抗平均下降13.0%。此外，该系统能够实现基于生物电效应的生物膜减少，这是通过施加低强度电场来执行的，该电场增加了生物膜细菌对抗菌剂的敏感性，最终减少了所需的抗生素剂量。结论：总的来说，这种改良的导管系统代表了使用基于器械的方法进行导管相关尿路感染（CITTI）管理的重要一步，将柔性电极与实际Foley导管沿着控制电子设备和移动的应用集成在一起。重要性：耐药性病原体的出现加剧了疟疾，是最普遍的医疗保健获得性感染之一，是一个重大挑战。这些感染是由细菌生物膜对留置导管的定殖驱动的。
Goal: This work introduces an integrated system incorporated seamlessly with a commercial Foley urinary catheter for bacterial growth sensing and biofilm treatment. Methods: The system is comprised of flexible, interdigitated electrodes incorporated with a urinary catheter via a 3D-printed insert for impedance sensing and bioelectric effect-based treatment. Each of the functions were wirelessly controlled using a custom application that provides a user-friendly interface for communicating with a custom PCB via Bluetooth to facilitate implementation in practice. Results: The integrated catheter system maintains the primary functions of indwelling catheters - urine drainage, balloon inflation - while being capable of detecting the growth of Escherichia coli, with an average decrease in impedance of 13.0% after 24 hours, tested in a newly-developed simulated bladder environment. Furthermore, the system enables bioelectric effect-based biofilm reduction, which is performed by applying a low-intensity electric field that increases the susceptibility of biofilm bacteria to antimicrobials, ultimately reducing the required antibiotic dosage. Conclusion: Overall, this modified catheter system represents a significant step forward for catheter-associated urinary tract infection (CAUTI) management using device-based approaches, integrating flexible electrodes with an actual Foley catheter along with the control electronics and mobile application. Significance: CAUTIs, exacerbated by the emergence of antibiotic-resistant pathogens, represent a significant challenge as one of the most prevalent healthcare-acquired infections. These infections are driven by the colonization of indwelling catheters by bacterial biofilms.