Dynamic changes of orexin A and leptin in obese children during body weight reduction
Dynamic changes of orexin A and leptin in obese children during body weight reduction
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DOI：
10.33549/physiolres.930860
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Prusa, R.
中科院分区：
文献类型：
--
作者：
Bronsky, J.;Nedvidkova, J.;Prusa, R.
在这项研究中，我们描述了下丘脑神经肽食欲素A在肥胖儿童的血浆水平的变化，在体重减轻及其与其他生化和人体测量参数的关系。我们用放射免疫分析法测定了58名肥胖儿童（33名女孩和25名男孩）的食欲素A空腹血浆水平;平均年龄为13.1 ± 0.38岁（范围7-18.5），在减肥治疗5周前后。测量所有受试者的瘦素、IGF-1和IGFBP-3水平，并与食欲素A水平和人体测量数据进行比较。减肥前受试者的平均体重为74.2 ± 2.79 kg，减肥后为67.4 ± 2.60 kg（p < 0.0001）。治疗前食欲素A水平为33.3 +/- 1.97 pg/ml，治疗后为51.7 +/- 3.07 pg/ml（p < 0.0001）。食欲素A水平在女孩和男孩之间没有显著差异（p = 0.7842）。食欲素A与年龄（r =-0.5395; p < 0.0001）、身高（r =-0.4751; p = 0.0002）、体重（r =-0.4030; p = 0.0017）和BMI（r =-0.2607; p = 0.0481）呈负相关。食欲素A与IGF-1、IGFBP-3和瘦素之间无相关性。食欲素A血浆水平增加体重减轻，而相反的是真实的瘦素水平。这些发现支持了食欲素A可能参与调节儿童营养状况的假设。
In this study, we describe changes of plasma levels of the hypothalamic neuropeptide orexin A in obese children during the reduction of body weight and its relationship to other biochemical and anthropometrical parameters. We measured orexin A fasting plasma levels by the RIA method in 58 obese children - 33 girls and 25 boys; mean age 13.1 +/- 0.38 years (range 7-18.5) before and after 5 weeks of weight-reduction therapy. Leptin, IGF-1, and IGFBP-3 levels were measured in all the subjects and were compared to orexin A levels and anthropometrical data. Average weight in subjects before weight-reduction was 74.2 +/- 2.79 kg and after weight-loss 67.4 +/- 2.60 kg (p < 0.0001). Orexin A levels before the therapy were 33.3 +/- 1.97 pg/ml and after the therapy 51.7 +/- 3.07 pg/ml (p < 0.0001). Levels of orexin A were not significantly different between girls and boys (p = 0.7842). We found negative correlation between orexin A and age (r = - 0.5395; p < 0.0001), body height (r = - 0.4751; p = 0.0002), body weight (r = - 0.4030; p = 0.0017) and BMI (r = - 0.2607; p = 0.0481). No correlation was found between orexin A and IGF-1, IGFBP-3 or leptin. Orexin A plasma levels increased during body weight loss, whereas the reverse was true for leptin levels. These findings support the hypothesis that orexin A may be involved in regulation of nutritional status in children.