Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia.
Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia.
复制标题
急性和慢性高血糖中的血管灌注和血脑葡萄糖转运。
DOI：
10.1111/j.1471-4159.1988.tb01179.x
复制
发表时间：
1988
影响因子：
4.7
通讯作者：
LaManna,JC
中科院分区：
文献类型：
--
作者：
Harik,SI;LaManna,JC
我们研究了急性和链脲佐菌素诱导的慢性高血糖对清醒大鼠局部脑血流和灌注特性以及葡萄糖跨血脑屏障的局部转运的影响。我们发现：（1）急性和慢性高血糖症患者局部脑血流量普遍减少;（2）慢性高血糖症（而非急性高血糖症）与脑L-葡萄糖空间显著和弥漫性减少相关;（3）慢性高血糖症不会改变血液-脑葡萄糖转运。总之，这些结果表明，在链脲佐菌素诱导的慢性高血糖症中，灌注脑毛细血管的比例减少和/或脑内皮膜特性改变，导致葡萄糖的非载体扩散减少。
We studied the effects of acute and streptozotocin‐induced chronic hyperglycemia on regional brain blood flow and perfusion characteristics, and on the regional transport of glucose across the blood‐brain barrier in awake rats. We found (1) a generalized decrease in regional brain blood flow in both acute and chronic hyperglycemia; (2) that chronic, but not acute, hyperglycemia is associated with a marked and diffuse decrease in brain l‐glucose space; and (3) that chronic hyperglycemia does not alter blood‐to‐brain glucose transport. Taken together, these results suggest that in streptozotocin‐induced chronic hyperglycemia, there is a reduction in the proportion of perfused brain capillaries and/or an alteration in brain endothelial membrane properties resulting in decreased noncarrier diffusion of glucose.