Anatomy of Mammalian Replication Domains.
Anatomy of Mammalian Replication Domains.
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DOI：
10.3390/genes8040110
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发表时间：
2017-03-28
期刊：
影响因子：
3.5
通讯作者：
Okumura K
中科院分区：
文献类型：
--
作者：
Takebayashi SI;Ogata M;Okumura K
遗传信息通过DNA复制通过多轮细胞分裂忠实地复制。在哺乳动物中，DNA以Mb大小的染色体单位复制，称为“复制域”。虽然在多种细胞类型和疾病状态下的全基因组图谱已经揭示了复制结构域的动态和静态特性，但我们仍在了解产生这些特性的机制。更好地理解复制域调控的分子基础将为染色体结构和功能带来新的见解。
Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called “replication domains.” While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give rise to these properties. A better understanding of the molecular basis of replication domain regulation will bring new insights into chromosome structure and function.