ID(ealizing) control of adult subventricular zone neural stem/precursor cell differentiation for CNS regeneration
ID(ealizing) control of adult subventricular zone neural stem/precursor cell differentiation for CNS regeneration
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ID（实现）控制成人室下区神经干/前体细胞分化以促进中枢神经系统再生
DOI：
10.1080/23262133.2016.1223532
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Schachtrup C.
中科院分区：
文献类型：
--
作者：
Bohrer C;Schachtrup C.
成人中枢神经系统（CNS）被认为是一个相对静止的组织，细胞更新很少。现在已经确定，有更多的可塑性比以前认为，星形胶质细胞作为神经干细胞/前体细胞（NSPCs）在脑室下区（SVZ）。这些NSPCs可以产生有限数量的新神经元、反应性星形胶质细胞和少突胶质细胞，有助于CNS疾病的脑修复，这一发现为利用这些细胞进行治疗干预带来了希望。在这里，我们将讨论成年NSPC分化成星形胶质细胞在中枢神经系统疾病的螺旋-环-螺旋转录因子蛋白家族的转录控制。在我们最近的研究中，我们报告了皮质损伤后成人NSPC亚群中BMP-2水平升高会转化为Id 3表达的增加。然后Id 3与碱性螺旋-环-螺旋转录因子E47异二聚化，并释放E47介导的对星形胶质细胞特异性基因表达的抑制。因此，成人NSPCs优先分化为星形胶质细胞。我们相信，了解成年哺乳动物脑中NSPCs的体内分化潜力和分子基础将有助于我们评估它们对脑修复的贡献，并可能导致治疗人类CNS疾病的新概念。
The adult central nervous system (CNS) was considered a comparatively static tissue with little cell turnover. It is now well established that there is more plasticity than previously thought and that astrocytes act as neural stem/precursor cells (NSPCs) in the subventricular zone (SVZ). The discovery that these NSPCs can give rise to a limited number of new neurons, reactive astrocytes and oligodendrocytes contributing to brain repair in CNS disease, has raised hopes toward harnessing these cells for therapeutic interventions. Here, we will discuss the transcriptional control of adult NSPC differentiation into astrocytes in CNS disease focusing on the helix-loop-helix transcription factor protein family. In our recent study, we reported that elevated BMP-2 levels are translated into an increase in Id3 expression in adult NSPC subpopulations after cortical injury. Id3 then heterodimerizes with the basic helix-loop-helix transcription factor E47 and releases the E47‐mediated repression of astrocyte‐specific gene expression. Consequently, adult NSPCs preferentially differentiate into astrocytes. We believe that understanding thein vivodifferentiation potential and the molecular underpinnings of NSPCs in the adult mammalian brain will help us to evaluate their contributions to brain repair and may lead to new concepts in treating human CNS diseases.
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影响因子：
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