Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male rats.
Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male rats.
复制标题
产前接触可卡因会扰乱青少年和成年雄性大鼠的非空间短期记忆。
DOI：
10.1016/s0166-4328(01)00338-2
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发表时间：
2002
影响因子：
2.7
通讯作者：
Roth,RobertH
中科院分区：
文献类型：
--
作者：
Morrow,BretA;Elsworth,JohnD;Roth,RobertH
在过去二十年中，娱乐性使用可卡因的人数有所增加，导致胎儿接触毒品的健康问题日益受到关注。研究人员注意到，暴露在环境中的儿童，在复杂或分散注意力的情况下，认知表现会发生改变，但在更可控的情况下则不会。在啮齿类动物模型中，虽然这些研究在给药途径和给药模式上也有所不同，但在一些范例中（但不是全部）发现了短期记忆缺陷。在这里，我们报告了短期记忆缺陷的大鼠产前暴露于可卡因使用静脉注射模型，更接近模拟可卡因剂量和药代动力学与人类使用。采用自发双目标识别任务来避免(1)明显的厌恶或奖励成分，(2)参考记忆成分和(3)外部激励因素的使用，如游泳压力或食物剥夺/奖励。在这项任务中，在子宫内暴露于可卡因的青春期和成年雄性大鼠与生理盐水对照组相比，表现出短期记忆的缺陷。产前可卡因组和生理盐水组的大鼠在探索物体的时间和失败次数上没有差别。这项研究表明，产前接触可卡因会导致自发执行任务时非空间短期记忆的长期缺陷。
The rise in the recreational use of cocaine in the last two decades has resulted in a growing health concern about fetal drug exposure. In exposed children, investigators have noted altered cognitive performance in complex or distracting, but not more controlled, situations. In rodent models, deficits in short-term memory have been noted in some, but not all, paradigms, although these studies also differ in routes of administration and dosing models. Here, we report short-term memory deficits in rats prenatally exposed to cocaine using an intravenous administration model to closer mimic cocaine doses and pharmacokinetics seen with human use. A spontaneous two object recognition task was used to avoid (1) clearly aversive or rewarding components, (2) reference memory component and (3) the use of external motivators, such as swimming stress or food deprivation/rewards. In this task, adolescent and adult male rats exposed to cocaine in utero demonstrated deficits in short-term memory compared with saline controls. No difference in the time spent exploring the objects or the number of failures was noted between the prenatal cocaine and saline rats. This study suggests that prenatal exposure to cocaine can result in a long-lasting deficit in non-spatial, short-term memory in a spontaneously performed task.