Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa.
Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa.
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DOI：
10.1038/s41598-017-16640-7
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发表时间：
2017-11-27
影响因子：
4.6
通讯作者：
Terasaki H
中科院分区：
文献类型：
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作者：
Sayo A;Ueno S;Kominami T;Nishida K;Inooka D;Nakanishi A;Yasuda S;Okado S;Takahashi K;Matsui S;Terasaki H
本研究的目的是通过Humphrey field Analyzer 10-2程序（HFA 10-2）确定色素性视网膜炎（RP）患者视野缺损的进展情况。回顾了45例RP患者至少3次视野检查的45只眼的医疗记录。采用线性混合模型跟踪4、12、20个点的平均偏差和平均灵敏度的变化，三个同心圆正方形分别为S4、S12、S20。中位随访时间为3.86年[范围：1.93 ~ 9.86，IQR（四分位数间距）：3.01 ~ 4.93]。视野测试的中位数为3次（范围：3至15次，IQR: 3至4次）。MD的平均变化为- 0.46 dB/年（- 5.80%/年）。当患者按平均初始MD分组时，在S4， S12和S20中，较不晚期组的进展速度比较晚期组慢。这些结果将有助于了解中央视野RP的病理变化。
The aim of this study is to determine the progress of the visual field defects obtained by the Humphrey Field Analyzer 10-2 program (HFA 10-2) in patients with retinitis pigmentosa (RP). The medical records of 45 eyes of 45 RP patients who had at least 3 visual field tests were reviewed. Linear mixed models were used to follow the changes of the mean deviation and the average sensitivity of 4, 12, and 20 points in three concentric squares, designated as S4, S12, and S20. The median follow-up time was 3.86 years [range: 1.93 to 9.86, IQR (Interquartile range): 3.01 to 4.93]. The median number of the visual field tests was 3 (range: 3 to 15, IQR: 3 to 4). The mean change of the MD was −0.46 dB/year (−5.80%/year). When the patients were grouped by the average initial MD, the less advanced group had slower progressions than the more advanced group in S4, S12, and S20. These results should be useful in understanding the pathological changes of RP in the central visual field.