Depression-related disturbances in rat maternal behaviour are associated with altered monoamine levels within mesocorticolimbic structures.
Depression-related disturbances in rat maternal behaviour are associated with altered monoamine levels within mesocorticolimbic structures.
复制标题
大鼠母性行为中与抑郁相关的紊乱与中皮质边缘结构内单胺水平的改变有关。
DOI：
10.1111/jne.12766
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发表时间：
2019
影响因子：
3.2
通讯作者：
Pereira,Mariana
中科院分区：
文献类型：
--
作者：
Winokur,SarahB;Lopes,KeiannaL;Moparthi,Yashaswani;Pereira,Mariana
母亲敏感地调整自己的母性反应以适应其发育中的子女的需求的能力，是健康的母子关系的基础。控制母亲如何根据孩子需求的动态变化调整照顾方式的生物学机制仍然是一个悬而未决的问题。在本研究中，我们研究了在离散的中皮质边缘结构中单胺水平的变化是否调节了产后护理的灵活性，这些结构涉及对育儿至关重要的认知和动机过程。本研究采用Wistar‐Kyoto （WKY）抑郁动物模型和对照Sprague‐Dawley （SD）大鼠，它们在认知、动机和育儿表现上存在显著差异。采用高效液相色谱电化学检测的方法，测定了产后早期（产后7 ~ 8天）、晚期（产后15 ~ 16天）和断奶后（产后25天）SD和WKY母亲的内侧前额叶皮质、纹状体、伏隔核和内侧视前区单胺类神经递质、多巴胺、去甲肾上腺素和血清素及其主要代谢物的水平。与我们之前的工作一致，我们发现随着产后时间的推移，SD母亲的照顾减少了。与未生育的雌性相比，产后早期的母亲细胞内单胺浓度较低，去甲肾上腺素含量较低，大多数结构内血清素含量较高。产后行为轨迹随后与多个结构中所有三种单胺水平的逐渐增加相对应。与SD母亲相比，WKY母亲在照顾子女方面表现出不一致和混乱，并且在母性行为方面表现出严重的缺陷。此外，与SD母亲相比，WKY母亲的这三种单胺含量普遍较低，并且在产后期间的变化模式不同，这表明WKY母亲在过渡和经历母亲身份时中枢单胺通路功能失调。综上所述，本研究的结果表明单胺在多个中皮质边缘结构中的作用，与调节照顾行为相适应，以适应年轻人不断变化的需求。
The ability of mothers to sensitively attune their maternal responses to the needs of their developing young is fundamental to a healthy mother‐young relationship. The biological mechanisms that govern how mothers adjust caregiving to the dynamic changes in the demands of the young remain an open question. In the present study, we examined whether changes in monoamine levels, within discrete mesocorticolimbic structures involved in cognitive and motivational processes key to parenting, modulate this flexibility in caregiving across the postpartum period. The present study used a Wistar‐Kyoto (WKY) animal model of depression and control Sprague‐Dawley (SD) rats, which differ dramatically in their cognitive, motivational, and parenting performance. Levels of the monoamine neurotransmitters, dopamine, noradrenaline and serotonin, as well as their major metabolites, were measured within the medial prefrontal cortex, striatum, nucleus accumbens and medial preoptic area of SD and WKY mothers at early (postpartum day [PPD]7‐8), late (PPD15‐16) and weaning (PPD25) postpartum stages using high‐performance liquid chromatography with electrochemical detection. Consistent with our prior work, we find that caregiving of SD mothers declined as the postpartum period progressed. Relative to nulliparous females, early postpartum mothers had lower intracellular concentrations of monoamines, as well as lower noradrenaline turnover, and an elevated serotonin turnover within most structures. Postpartum behavioural trajectories subsequently corresponded to a progressive increase in all three monoamine levels within multiple structures. Compared to SD mothers, WKY mothers were inconsistent and disorganised in caring for their offspring and exhibit profound deficits in maternal behaviour. Additionally, WKY mothers had generally lower levels of all three monoamines, as well as different patterns of change across the postpartum period, compared to SD mothers, suggesting dysfunctional central monoamine pathways in WKY mothers as they transition and experience motherhood. Taken together, the results of the present study suggest a role for monoamines at multiple mesocorticolimbic structures with repect to modulating caregiving behaviours attuned to the changing needs of the young.