Extracting and compensating dispersion mismatch in ultrahigh-resolution Fourier domain OCT imaging of the retina
Extracting and compensating dispersion mismatch in ultrahigh-resolution Fourier domain OCT imaging of the retina
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DOI：
10.1364/oe.20.025357
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发表时间：
2012-11-05
期刊：
影响因子：
3.8
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
--
作者：
Choi, WooJhon;Baumann, Bernhard;Fujimoto, James G.
提出了一种数值方法来提取超高分辨率傅立叶域光学相干层析成像（OCT）的视网膜的色散失配。该方法利用与Shack-Hartmann波前传感器的类比。通过利用光学成像中的像差和光谱/傅立叶域OCT中的色散失配的表达式之间的数学相似性，ShackHartmann原理可以从二维近轴波矢量空间（或空间域中的x-y平面）扩展到一维波数空间（或空间域中的z轴）。对于视网膜的OCT成像，不同的视网膜层，例如视网膜神经纤维层（RNFL）、感光器内节和外节连接（IS/OS）或视网膜色素上皮（RPE）附近的所有视网膜层，可以用作轴向方向上的点源信标，类似于在用于像差表征的常规二维Shack-Hartman波前传感器中使用的点源信标。光学成像中的斑点现象的微妙之处，影响自适应光学中使用的夏克-哈特曼波前传感器，也类似地出现在本申请中。使用这种方法并仔细抑制散斑，可以成功地从数值上提取光谱/傅立叶域OCT视网膜成像中的色散失配，并用于数值色散补偿，以生成更清晰的超高分辨率OCT图像。(C)2012美国光学学会
We present a numerical approach to extract the dispersion mismatch in ultrahigh-resolution Fourier domain optical coherence tomography (OCT) imaging of the retina. The method draws upon an analogy with a Shack-Hartmann wavefront sensor. By exploiting mathematical similarities between the expressions for aberration in optical imaging and dispersion mismatch in spectral / Fourier domain OCT, ShackHartmann principles can be extended from the two-dimensional paraxial wavevector space (or the x-y plane in the spatial domain) to the one-dimensional wavenumber space (or the z-axis in the spatial domain). For OCT imaging of the retina, different retinal layers, such as the retinal nerve fiber layer (RNFL), the photoreceptor inner and outer segment junction (IS/OS), or all the retinal layers near the retinal pigment epithelium (RPE) can be used as point source beacons in the axial direction, analogous to point source beacons used in conventional two-dimensional Shack-Hartman wavefront sensors for aberration characterization. Subtleties regarding speckle phenomena in optical imaging, which affect the Shack-Hartmann wavefront sensor used in adaptive optics, also occur analogously in this application. Using this approach and carefully suppressing speckle, the dispersion mismatch in spectral / Fourier domain OCT retinal imaging can be successfully extracted numerically and used for numerical dispersion compensation to generate sharper, ultrahigh-resolution OCT images. (C) 2012 Optical Society of America