PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseri meningitidis
PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseri meningitidis
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DOI：
10.1128/aac.47.10.3336-3338.2003
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发表时间：
2003-10-01
影响因子：
4.9
通讯作者：
Cafferkey, MT
中科院分区：
文献类型：
--
作者：
Bennett, DE;Cafferkey, MT
我们发现了一个以前未记录的突变，在二氢蝶酸合酶（folP）基因与脑膜炎奈瑟菌磺胺耐药。开发了一种基于PCR的检测该突变的方法，该方法可100%预测磺胺类药物耐药性。
We identified a previously undocumented mutation in the dihydropteroate synthase (folP) gene associated with Neisseria meningitidis sulfonamide resistance. A PCR-based assay to detect this mutation, which is 100% predictive of sulfonamide resistance, was developed.