Interplay between chromatin modifications and paused RNA polymerase II in dynamic transition between stalled and activated genes
Interplay between chromatin modifications and paused RNA polymerase II in dynamic transition between stalled and activated genes
复制标题
染色质修饰与暂停 RNA 聚合酶 II 在停滞基因和激活基因之间动态转换中的相互作用
DOI：
10.1111/j.1469-185x.2012.00237.x
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发表时间：
2013-02-01
影响因子：
10
通讯作者：
Tao, Yongguang
中科院分区：
文献类型：
--
作者：
Liu, Shuang;Tao, Yongguang
染色质修饰（例如DNA甲基化）和RNA聚合酶II（Pol II）之间的动态相互作用在干细胞发育、建立和维持期间的基因转录中以及在细胞对细胞外刺激（例如导致DNA损伤的刺激）的反应中起关键作用。Pol II在称为Pol II停滞的过程中以高浓度被募集到许多失活基因的启动子近端区域。这是基因激活之前的一个关键过程，涉及许多相互作用的因素。包括核小体位置在内的染色质修饰依赖于染色质结构。停滞基因产生染色质的特定结构构象，其充当染色质修饰的靶标。这样，Pol II停滞可以被认为是在停滞和激活基因之间的动态转换期间在这些区域中染色质修饰的一种信号。
The dynamic interplay between chromatin modification (e.g. DNA methylation) and RNA polymerase II (Pol II) plays a critical role in gene transcription during stem cell development, establishment, and maintenance and in the cellular response to extracellular stimuli such as those that cause DNA damage. Pol II is recruited to the promoter‐proximal regions of numerous inactive genes at high conentrations in a process called Pol II stalling. This is a key process prior to gene activation and it involves many interacting factors. Chromatin modification including nucleosome position is dependent on chromatin structure. Stalled genes create a particular structural conformation of chromatin, which acts as a target for chromatin modification. In this way, Pol II stalling may be regarded as a type of signal for chromatin modification in these regions during the dynamic transition between stalled and activated genes.