A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
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DOI：
10.7150/jca.57019
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发表时间：
2021
影响因子：
3.9
通讯作者：
Peng YH
中科院分区：
文献类型：
--
作者：
Hong CQ;Weng XF;Huang XC;Chu LY;Wei LF;Lin YW;Chen LY;Liu CT;Xu YW;Peng YH
我们以前发现了一组针对多种肿瘤相关抗原（BMI-1，HSP 70，MMP-7，NY-ESO-1，p53和PRDX 6）的自身抗体，这些抗体可能有助于早期检测食管胃交界处腺癌和食管鳞状细胞癌。在这里，我们旨在评估这些自身抗体在乳腺癌患者中的诊断性能。应用酶联免疫吸附试验检测123例乳腺癌患者和123例正常人血清中的自身抗体。我们采用逻辑回归分析来确定用于诊断的优化自身抗体生物标志物和用于分析诊断效率的受试者操作特征。6种自身抗体中的5种，BMI-1、HSP 70、NY-ESO-1、p53和PRDX 6在乳腺癌中的血清水平与正常对照相比显著升高。由针对BMI-1、HSP 70、NY-ESO-1和p53的自身抗体组成的优化组显示用于诊断乳腺癌的曲线下面积（AUC）为0.819（95%CI 0.766-0.873）、63.4%灵敏度和90.2%特异性。此外，该自身抗体组可以区分早期乳腺癌患者和正常对照，AUC为0.805（95%CI 0.743-0.886），敏感性为59.6%，特异性为90.2%。我们的研究结果表明，BMI-1，HSP 70，NY-ESO-1和p53作为血清生物标志物的自身抗体组有可能帮助检测早期乳腺癌。
We previously found a panel of autoantibodies against multiple tumor-associated antigens (BMI-1, HSP70, MMP-7, NY-ESO-1, p53 and PRDX6) that might facilitate early detection of esophagogastric junction adenocarcinoma and esophageal squamous cell carcinoma. Here we aimed at assessing the diagnostic performance of these autoantibodies in breast cancer patients. Enzyme-linked immunosorbent assay was applied to detect sera autoantibodies in 123 breast cancer patients and 123 age-matched normal controls. We adopted logistic regression analysis to identify optimized autoantibody biomarkers for diagnosis and receiver-operating characteristics to analyze diagnostic efficiency. Five of six autoantibodies, BMI-1, HSP70, NY-ESO-1, p53 and PRDX6 demonstrated significantly elevated serum levels in breast cancer compared to normal controls. An optimized panel composed of autoantibodies to BMI-1, HSP70, NY-ESO-1 and p53 showed an area under the curve (AUC) of 0.819 (95% CI 0.766-0.873), 63.4% sensitivity and 90.2% specificity for diagnosing breast cancer. Moreover, this autoantibody panel could differentiate patients with early stage breast cancer from normal controls, with AUC of 0.805 (95% CI 0.743-0.886), 59.6% sensitivity and 90.2% specificity. Our findings indicated that the panel of autoantibodies to BMI-1, HSP70, NY-ESO-1 and p53 as serum biomarkers have the potential to help detect early stage breast cancer.
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影响因子：
10.3
作者：
Kirsh, Victoria A.;Chiarelli, Anna M.;Boyd, Norman F.
通讯作者：
Boyd, Norman F.
影响因子：
158.5
作者：
Bleyer, Archie;Welch, H. Gilbert
通讯作者：
Welch, H. Gilbert
关键评估用于分类或预测的生物标志物的准确性：研究设计标准。
影响因子：
10.3
作者：
Pepe, Margaret S.;Feng, Ziding;Janes, Holly;Bossuyt, Patrick M.;Potter, John D.
通讯作者：
Potter, John D.
DOI：
10.1016/j.jtho.2016.08.143
发表时间：
2017-03
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Massion PP;Healey GF;Peek LJ;Fredericks L;Sewell HF;Murray A;Robertson JF
通讯作者：
Robertson JF
影响因子：
8.8
作者：
Heinavaara, S.;Sarkeala, T.;Anttila, A.
通讯作者：
Anttila, A.