Noise in the nervous system.

Noise in the nervous system.
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DOI:
10.1038/nrn2258
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发表时间:
2008-04
影响因子:
34.7
通讯作者:
Wolpert, Daniel M.
Wolpert, Daniel M.
中科院分区:
医学1区
文献类型:
--
作者:
Faisal, A. Aldo;Selen, Luc P. J.;Wolpert, Daniel M.

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信号的随机干扰,称为“噪声”,对信息处理构成了一个基本问题,并影响神经系统功能的各个方面。然而,噪声在神经系统中的性质、数量和影响直到最近才以定量的方式得到解决。实验和计算方法表明,多个噪声源有助于细胞和行为的试验到试验的变异性。我们回顾了神经系统中噪音的来源,从分子到行为水平,并展示了噪音如何影响试验间的变异性。我们强调噪声如何影响神经网络和神经系统适用于对抗噪声的有害影响的原则,并简要讨论噪声的潜在好处。
Random disturbances of signals, termed ‘noise’, pose a fundamental problem for information processing and affect all aspects of nervous-system function. However, the nature, amount and impact of noise in the nervous system have only recently been addressed in a quantitative manner. Experimental and computational methods have shown that multiple noise sources contribute to cellular and behavioural trial-to-trial variability. We review the sources of noise in the nervous system, from the molecular to the behavioural level, and show how noise contributes to trial-to-trial variability. We highlight how noise affects neuronal networks and the principles the nervous system applies to counter detrimental effects of noise, and briefly discuss noise's potential benefits.
DOI: 10.1016/s0896-6273(03)00680-9
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