The relationship between salivary biomarkers and State-Trait Anxiety Inventory score under mental arithmetic stress: A pilot study.
The relationship between salivary biomarkers and State-Trait Anxiety Inventory score under mental arithmetic stress: A pilot study.
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DOI：
10.1213/01.ane.0000184196.60838.8d
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发表时间：
2005-12-01
影响因子：
5.7
通讯作者：
Hirota, K
中科院分区：
文献类型：
--
作者：
Noto, Y;Sato, T;Hirota, K
应激激素的测定是一种常用的客观评价精神应激的方法。然而，仅采血的压力也可能增加应激激素水平。在本研究中，我们在非侵入性条件下从健康志愿者中采集唾液生物标志物，并确定其评估精神压力的有效性。具体来说，我们研究了状态焦虑量表评分（STAI-S）的受试者暴露于算术压力和唾液嗜铬粒蛋白-A，α-淀粉酶，或皮质醇之间的关系。STAI-s与唾液α-淀粉酶显著相关（r = 0.589; P < 0.01），与唾液嗜铬粒蛋白A和皮质醇无相关性。因此，唾液a-淀粉酶是心理社会压力的有用指标。
Measurement of stress hormones is a common objective method for assessment of mental stress. However, the stress of blood sampling alone may also increase stress hormone levels. In the present study, we sampled salivary biomarkers from healthy volunteers under noninvasive conditions and determined their efficacy to assess mental stress. Specifically, we examined the relationship between State Anxiety Inventory score (STAI-s) in subjects exposed to arithmetic stress and salivary chromogranin-A, a-amylase, or cortisol. The STAI-s was significantly correlated to salivary a-amylase (r = 0.589; P < 0.01) but not to salivary chromogranin-A or cortisol. Therefore, salivary a-amylase is a useful indicator of psychosocial stress.