The Thalamostriatal Projections Contribute to the Initiation and Execution of a Sequence of Movements
The Thalamostriatal Projections Contribute to the Initiation and Execution of a Sequence of Movements
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DOI：
10.1016/j.neuron.2018.09.052
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发表时间：
2018-11-07
期刊：
影响因子：
16.2
通讯作者：
Tecuapetla, Fatuel
中科院分区：
文献类型：
--
作者：
Diaz-Hernandez, Edgar;Contreras-Lopez, Ruben;Tecuapetla, Fatuel
驱动纹状体活动的主要输入之一是丘脑纹状体投射。虽然假设不同的丘脑纹状体投射对纹状体功能的形成有不同的贡献的假说在很大程度上被接受，但现有的技术限制阻碍了证明这一点的努力。在这里，通过使用逆行光识别丘脑纹状体神经元的电生理记录和丘脑纹状体末梢的光遗传学抑制，我们发现丘脑束旁和丘脑腹后区的丘脑纹状体投射有助于运动序列的顺利启动和适当执行。我们的结果支持了这样一个模型，其中两个丘脑纹状体投射对序列的启动和执行都有特定的贡献，强调了腹后丘脑纹状体连接对动作重复的特定贡献。
One of the main inputs driving striatal activity is the thalamostriatal projection. While the hypothesis postulating that the different thalamostriatal projections contribute differentially to shape the functions of the striatum is largely accepted, existing technical limitations have hampered efforts to prove it. Here, through the use of electrophysiological recordings of antidromically photo-identified thalamostriatal neurons and the optogenetic inhibition of thalamostriatal terminals, we identify that the thalamostriatal projections from the parafascicular and the ventroposterior regions of the thalamus contribute to the smooth initiation and the appropriate execution of a sequence of movements. Our results support a model in which both thalamostriatal projections have specific contributions to the initiation and execution of sequences, highlighting the specific contribution of the ventroposterior thalamostriatal connection for the repetition of actions.