Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study
Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study
复制标题
网络成瘾症的区域同质性增加：静息态功能磁共振成像研究
DOI：
10.3760/cma.j.issn.0366-6999.2010.14.014
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发表时间：
2010-07-20
影响因子：
6.1
通讯作者：
Li Ling-jiang
中科院分区：
文献类型：
--
作者：
Liu Jun;Gao Xue-ping;Li Ling-jiang
背景网络成瘾（Internet add disorder，简称IAD）已成为我国青少年严重的心理健康问题。然而，IAD的发病机制尚不清楚。本研究目的应用区域均匀性（ReHo）方法分析静息状态下IAD大学生的脑功能特征。方法对19名IAD大学生和19名对照组进行静息状态下的功能磁共振成像（fMRI）检查。采用ReHo法分析两组患者平均ReHo的差异。结果与对照组相比，IAD组的ReHo脑区增加：小脑、脑干、右侧扣带回、双侧副海马、右侧额叶（直肠回、额下回和额中回）、左侧额上回、左侧楔前叶、右侧中央后回、右侧枕中回、右侧颞下回、左侧颞上回和颞中回。与对照组相比，IAD组未发现ReHo脑区减少。结论与对照组相比，IAD大学生脑区同步性存在异常，大部分脑区同步性增强。结果反映了IAD大学生脑功能的变化。小脑、脑干、边缘叶、额叶和顶叶之间同步增强的联系可能与奖赏通路有关。中华医学杂志2010；123 (14): 1904 - 1908
Background Internet addition disorder (IAD) is currently becoming a serious mental health problem among Chinese adolescents. The pathogenesis of IAD, however, remains unclear. The purpose of this study applied regional homogeneity (ReHo) method to analyze encephalic functional characteristic of IAD college students under resting state.Methods Functional magnetic resonanc image (fMRI) was performed in 19 IAD college students and 19 controls under resting state. ReHo method was used to analyze the differences between the average ReHo in two groups.Results The following increased ReHo brain regions were found in IAD group compared with control group: cerebellum, brainstem, right cingulate gyrus, bilateral parahippocampus, right frontal lobe (rectal gyrus, inferior frontal gyrus and middle frontal gyrus), left superior frontal gyrus, left precuneus, right postcentral gyrus, right middle occipital gyrus, right inferior temporal gyrus, left superior temporal gyrus and middle temporal gyrus. The decreased ReHo brain regions were not found in the IAD group compared with the control group.Conclusions There are abnormalities in regional homogeneity in IAD college students compared with the controls and enhancement of synchronization in most encephalic regions can be found. The results reflect the functional change of brain in IAD college students. The connections between the enhancement of synchronization among cerebellum, brainstem, limbic lobe, frontal lobe and apical lobe may be relative to reward pathways. Chin Med J 2010;123(14):1904-1908