Association between Objectively Measured Physical Activity and Mortality in NHANES.
Association between Objectively Measured Physical Activity and Mortality in NHANES.
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DOI：
10.1249/mss.0000000000000885
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发表时间：
2016-07
影响因子：
4.1
通讯作者：
Murphy R
中科院分区：
文献类型：
--
作者：
Fishman EI;Steeves JA;Zipunnikov V;Koster A;Berrigan D;Harris TA;Murphy R
我们在一个具有全国代表性的老年人群样本中，将总体身体活动量、轻度身体活动量以及中等到高强度身体活动量（MVPA）作为死亡率的预测因素进行了研究。然后，我们探讨了用相同时长的轻度活动或中等到高强度身体活动替代久坐时间在理论上的影响。
利用加速度计测量的活动量，我们在2003 - 2006年美国国家健康与营养检查调查（n = 3029）中年龄在50 - 79岁的成年人中，研究了总体活动计数、轻度（每分钟100 - 2019计数）以及中等到高强度（每分钟>2019计数）活动计数与死亡率之间的关联，并对这些人进行了随访直至2011年12月。我们采用考克斯比例风险模型来估计死亡风险。使用等时替代模型来研究用轻度活动或中等到高强度身体活动替代久坐时间对死亡率在理论上的影响。
在对潜在的混杂因素进行调整后，包括年龄、性别、种族/民族、教育程度、体重指数以及是否存在合并症等，总体活动计数处于最高三分位数的人群死亡风险是处于最低三分位数人群的五分之一（风险比：0.21，95%置信区间：0.12，0.38），处于中间三分位数的人群死亡风险是处于最低三分位数人群的三分之一（风险比：0.36，95%置信区间：0.30，0.44）。此外，用轻度活动替代30分钟的久坐时间与死亡风险的显著降低相关（随访5年后：风险比 = 0.80，95%置信区间：0.75，0.85）。用中等到高强度身体活动替代30分钟的久坐时间也与死亡风险的降低相关（风险比 = 0.49，95%置信区间：0.25，0.97）。
总体活动量越大，全因死亡风险越低。用轻度活动或中等到高强度身体活动替代久坐时间可能会降低老年人的死亡风险。
We examined total, light, and moderate-to-vigorous physical activity (MVPA) as predictors of mortality in a nationally representative sample of older adults. Then, we explored the theoretical consequences of replacing sedentary time with the same duration of light activity or MVPA. Using accelerometer measured activity, the associations between total, light (100 to 2019 counts per minute), and moderate-to-vigorous (>2019 counts per minute) activity counts and mortality were examined in adults aged 50 to 79 in the National Health and Nutrition Examination Survey, 2003-2006 (n=3,029), with mortality follow-up through December 2011. Cox proportional hazards models were fitted to estimate mortality risks. An isotemporal substitution model was used to examine the theoretical consequences of replacing sedentary time with light activity or MVPA on mortality. After adjusting for potential confounders, including age, sex, race/ethnicity, education, body mass index, and the presence of comorbid conditions, those in the highest tertile of total activity counts had one fifth the risk of death of those in the lowest tertile (HR: 0.21, 95% CI: 0.12, 0.38), and those in the middle tertile had one third the risk of death (HR: 0.36, 95% CI: 0.30, 0.44). In addition, replacing thirty minutes of sedentary time with light activity was associated with significant reduction in mortality risk (After 5 years of follow-up: HR = 0.80, 95% CI: 0.75, 0.85). Replacing thirty minutes of sedentary time with MVPA was also associated with reduction in mortality risk (HR = 0.49, 95% CI: 0.25, 0.97). Greater total activity is associated with lower all-cause mortality risk. Replacing sedentary time with light activity or MVPA may reduce mortality risk for older adults.