Caffeine improves bladder function in streptozotocin-induced diabetic rats
Caffeine improves bladder function in streptozotocin-induced diabetic rats
复制标题
咖啡因改善链脲佐菌素诱导的糖尿病大鼠的膀胱功能
DOI：
10.1002/nau.23799
复制
发表时间：
2019-01-01
影响因子：
2
通讯作者：
Ding, Liu-Cheng
中科院分区：
文献类型：
--
作者：
Liu, Ya-Dong;Zhang, Si-Cong;Ding, Liu-Cheng
Aims To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics. Methods Female Sprague-Dawley rats (n = 24) were divided into four groups: control group, DM group, DM + caffeine (5 mg/kg/day), and DM + caffeine (10 mg/kg/day). DM was induced by streptozotocin (STZ). Cystometric studies were conducted on all rats. After 8 weeks of treatment with caffeine, the urodynamic parameters, including bladder capacity, residual urine volume, voiding time, and peak voiding pressure, were measured. Results DM rats had a higher bladder capacity and post-void residual urine volume (PVR), an increased voiding time and peak voiding pressure, and a markedly lower voiding efficiency than the control group rats. After treatment with caffeine, bladder capacity, post-void residual urine volume, and peak voiding pressure were significant lower than those in the DM group, but voiding efficiency was markedly higher. Conclusion The results suggested that caffeine (5 or 10 mg/kg/day) may improve the bladder function at 8 weeks after STZ induction. Thus, this may represent a potential strategy to increase voiding efficiency in diabetes.
