Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.
Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.
复制标题
C-H锌锌通过C-H锌的铜催化的杂种氨基化氨化。
DOI：
10.1002/anie.201311029
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发表时间：
2014-04-25
期刊：
影响因子：
--
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
McDonald SL;Hendrick CE;Wang Q
杂芳烃和芳烃的直接胺化是在一锅C-H锌化/铜催化的亲电胺化过程中实现的。这种胺化方法提供了一种有效和快速地获得各种杂芳胺和芳香胺的方法，包括那些以前使用C-H胺化方法无法获得的芳香胺。反应条件温和，官能团相容性好，在合成重要复合胺方面具有很大的潜力。
Direct amination of heteroarenes and arenes has been achieved in a one-pot C–H zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C–H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.