Electrospinning of chitosan dissolved in concentrated acetic acid solution
Electrospinning of chitosan dissolved in concentrated acetic acid solution
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DOI：
10.1016/j.biomaterials.2005.01.066
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发表时间：
2005-09-01
期刊：
影响因子：
14
通讯作者：
Jang, JH
中科院分区：
文献类型：
--
作者：
Geng, XY;Kwon, OH;Jang, JH
以壳聚糖水溶液为原料，以浓醋酸溶液为溶剂，制备了壳聚糖纳米纤维。在电场为4kV/cm的条件下，将7%壳聚糖溶液在90%的醋酸水溶液中电纺成功，得到了平均纤维直径为130 nm的均匀纳米纤维毡。水溶液中的醋酸浓度高于30%是形成壳聚糖纳米纤维的必要条件，因为水射流中浓度越高，壳聚糖溶液的表面张力越低，而电荷密度对溶液粘度的影响越大。然而，90%以上的醋酸溶液不足以溶解足够的壳聚糖以形成可纺的粘性浓缩物。只有相对分子质量为106,000 g/mol的壳聚糖才能产生无珠状的壳聚糖纳米纤维，而相对分子质量为30,000和398,000 g/mol的低分子或高相对分子质量的壳聚糖则不能产生无珠壳聚糖纳米纤维。纤维的平均直径和粒度分布随电场的增大而减小，在5kV/cm或更高的电场下出现更多的珠状缺陷。(C)2005爱思唯尔有限公司。保留所有权利。
Chitosan nanofibers were electrospun from aqueous chitosan solution Using concentrated acetic acid solution as a solvent. A uniform nanofibrous mat of average fiber diameter of 130 nm was obtained from the following optimum condition: 7% chitosan solution in aqueous 90% acetic acid solution was successfully electrospun in the electric field of 4 kV/cm. The aqueous acetic acid concentration higher than 30%, was prerequisite for chitosan nanofiber formation, because more concentrated acetic acid in water Jet without significant progressively decreased surface tension of the chitosan solution and concomitantly increased charge density of effect on solution viscosity. However, acetic acid solution more than 90% did not dissolve enough chitosan to make spinnable viscous concentration. Only chitosan of a molecular weight of 106,000 g/mol produced bead-free chitosan nanofibers, while low- or high-molecular-weight chitosans of 30,000 and 398,000 g/mol did not. Average fiber diameters and size distribution decreased with increasing electric field and more bead defects appeared at 5 kV/cm or more. (c) 2005 Elsevier Ltd. All rights reserved.