Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study.
Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study.
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自然膀胱充盈在多个空间尺度上改变静息脑功能：一项MAPP网络神经影像学概念验证研究
DOI：
10.1038/s41598-020-76857-x
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发表时间：
2020-11-16
影响因子：
4.6
通讯作者：
Kutch JJ
中科院分区：
文献类型：
--
作者：
Mawla I;Schrepf A;Ichesco E;Harte SE;Klumpp DJ;Griffith JW;Strachan E;Yang CC;Lai H;Andriole G;Magnotta VA;Kreder K;Clauw DJ;Harris RE;Clemens JQ;Landis JR;Mullins C;Rodriguez LV;Mayer EA;Kutch JJ
人类调节尿液储存的神经回路在很大程度上是通过在向膀胱导管灌注液体驱动的尿动力学研究期间的功能性磁共振成像（fMRI）推断出来的。然而，尿动力学检测可能会因以高速率反复人工充盈膀胱并检查fMRI信号中相关的时间锁定变化而受到干扰。在此，我们描述并测试一种更具生态效度的范式来研究大脑对膀胱充盈的反应，具体方法是：（1）通过口服饮水使膀胱自然充盈；（2）检查静息态功能性磁共振成像（rs - fMRI），由于它与特定刺激无关，所以更自然；（3）将rs - fMRI测量值与自我报告（尿意）和生理测量值（排尿量）相关联。为了为未来的临床研究建立适当的对照和分析，在此我们分析从健康个体（N = 62）收集的数据，这些数据是慢性盆腔痛多学科研究方法（MAPP）研究网络的一部分。参与者口服约350毫升水，并在大约1小时后进行10分钟的“膀胱较充盈”rs - fMRI扫描。在排尿后立即进行第二次10分钟的“膀胱排空”rs - fMRI扫描。我们检查了大脑功能的多个空间尺度，包括局部活动、回路和网络。我们发现大脑功能的变化分布在排尿相关区域（例如，突显网络、感觉运动网络和默认网络的子区域），这些变化与刺激（尿量）和反应（尿意）显著相关。根据我们的研究结果，这种范式可在未来用于研究泌尿系统疾病的神经生物学基础。
Neural circuitry regulating urine storage in humans has been largely inferred from fMRI during urodynamic studies driven by catheter infusion of fluid into the bladder. However, urodynamic testing may be confounded by artificially filling the bladder repeatedly at a high rate and examining associated time-locked changes in fMRI signals. Here we describe and test a more ecologically-valid paradigm to study the brain response to bladder filling by (1) filling the bladder naturally with oral water ingestion, (2) examining resting state fMRI (rs-fMRI) which is more natural since it is not linked with a specific stimulus, and (3) relating rs-fMRI measures to self-report (urinary urge) and physiologic measures (voided volume). To establish appropriate controls and analyses for future clinical studies, here we analyze data collected from healthy individuals (N = 62) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Participants orally ingested approximately 350 mL of water, and had a 10 min “fuller bladder” rs-fMRI scan approximately 1 h later. A second 10 min “empty bladder” rs-fMRI scan was conducted immediately following micturition. We examined multiple spatial scales of brain function, including local activity, circuits, and networks. We found changes in brain function distributed across micturition loci (e.g., subregions of the salience, sensorimotor, and default networks) that were significantly related to the stimulus (volume) and response (urinary urge). Based on our results, this paradigm can be applied in the future to study the neurobiological underpinnings of urologic conditions.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
6.6
作者：
Kleinhans, Natalia M.;Yang, Claire C.;Strachan, Eric D.;Buchwald, Dedra S.;Maravilla, Kenneth R.
通讯作者：
Maravilla, Kenneth R.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
14.5
作者：
Athwal, BS;Berkley, KJ;Fowler, CJ
通讯作者：
Fowler, CJ