Detecting the translocation of DNA through a nanopore using graphene nanoribbons
Detecting the translocation of DNA through a nanopore using graphene nanoribbons
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DOI：
10.1038/nnano.2013.240
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发表时间：
2013-12-01
影响因子：
38.3
通讯作者：
Radenovic, A.
中科院分区：
文献类型：
--
作者：
Traversi, F.;Raillon, C.;Radenovic, A.
固态纳米孔可以作为单分子传感器，并有可能用于快速测序DNA分子。然而，纳米孔通常是在绝缘膜上制造的，厚度为15个碱基，这使得设备很难读取单个碱基。石墨烯只有0.335 nm厚（相当于DNA链中两个碱基之间的间距），因此可以为测序应用提供合适的膜。在这里，我们展示了固态纳米孔可以与石墨烯纳米带晶体管集成，以创建DNA易位传感器。当DNA分子穿过孔时，该装置可以同时测量晶体管中离子电流的下降和局部电压的变化，这两者都可以用来检测分子。我们研究了这两个信号之间的相关性，并使用离子电流测量作为石墨烯传感装置的实时控制。
Solid-state nanopores can act as single-molecule sensors and could potentially be used to rapidly sequence DNA molecules. However, nanopores are typically fabricated in insulating membranes that are as thick as 15 bases, which makes it difficult for the devices to read individual bases. Graphene is only 0.335 nm thick (equivalent to the spacing between two bases in a DNA chain) and could therefore provide a suitable membrane for sequencing applications. Here, we show that a solid-state nanopore can be integrated with a graphene nanoribbon transistor to create a sensor for DNA translocation. As DNA molecules move through the pore, the device can simultaneously measure drops in ionic current and changes in local voltage in the transistor, which can both be used to detect the molecules. We examine the correlation between these two signals and use the ionic current measurements as a real-time control of the graphene-based sensing device.