Stimulus duration in working memory is represented by neuronal activity in the monkey prefrontal cortex
Stimulus duration in working memory is represented by neuronal activity in the monkey prefrontal cortex
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DOI：
10.1111/j.1460-9568.2004.03525.x
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发表时间：
2004-08
影响因子：
3.4
通讯作者：
Y. Sakurai;Susumu Takahashi;M. Inoue
中科院分区：
文献类型：
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作者：
Y. Sakurai;Susumu Takahashi;M. Inoue
人类能够记住呈现的刺激的几个属性以及其呈现的持续时间。然而，在记忆中的刺激持续时间的神经代表仍然是未知的。本研究探讨了猴子在执行需要刺激持续时间的工作记忆的行为任务时，前额叶皮层单个神经元的活动。在这里，我们描述了特定的神经元，其放电率反映了编码或保留的持续时间的介绍刺激要记住。我们还描述了其他特定的神经元，其活动反映了编码或保留固定的持续时间，类似的，但无关的刺激持续时间在每个审判。其中一些特定的神经元表现出相同的持续时间相关放电，即使猴子正在执行不同的任务，其中不再需要刺激持续时间的工作记忆。从这些结果中，我们认为，在前额叶皮层的神经元在编码和保留的时间信息在工作记忆中发挥作用，这些神经元中的一些是专门用于表示的时间信息归因于刺激，即使时间信息是不必要的正确的性能。
Humans are capable of memorizing several attributes of a presented stimulus as well as its duration of presentation. However, the neuronal representation of stimulus duration in memory remains unknown. This study investigated activities of single neurons in the prefrontal cortex of monkeys while they were performing a behavioral task in which working memory for stimulus duration was needed. Here we describe specific neurons whose discharge rates reflect encoding or retention of the duration of the presentation of stimuli to be remembered. We also describe other specific neurons whose activities reflect encoding or retention of fixed duration, similar but unrelated to the stimulus duration presented in each trial. Some of these specific neurons showed the same duration‐related discharges even while the monkeys were performing a different task, in which working memory for stimulus duration was no longer needed. From these results, we suggest that neurons in the prefrontal cortex play roles in encoding and retention of temporal information in working memory and that some of those neurons are dedicated to representation of temporal information attributed to stimuli even when the temporal information is unnecessary for correct performance.