The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
复制标题
白介素1受体相关的T1/ST2的不存在不会影响T辅助细胞2型发育及其效应子功能。
DOI：
10.1084/jem.190.10.1541
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发表时间：
1999-11-15
影响因子：
15.3
通讯作者：
Akira, S
中科院分区：
文献类型：
--
作者：
Hoshino, K;Kashiwamura, S;Kuribayashi, K;Kodama, T;Tsujimura, T;Nakanishi, K;Matsuyama, T;Takeda, K;Akira, S
T1/ST 2是一种与白细胞介素（IL）-1受体家族同源的孤儿受体，在Th 2细胞表面组成型稳定表达，而在Th 1细胞表面不表达。T1/ST 2也在肥大细胞上表达，其对于Th 2介导的效应子应答是关键的。为了评估T1/ST 2是否是Th 2应答和肥大细胞功能所必需的，我们制备了T1/ST 2缺陷（T1/ST 2-/-）小鼠，并研究了T1/ST 2的作用。从T1/ST 2 −/−小鼠分离的初始CD 4 + T细胞在体外响应IL-4而发育为Th 2细胞。T1/ST 2 −/−小鼠在感染蠕虫寄生虫巴西日本圆线虫后以及过敏原诱导的气道炎症小鼠模型中表现出正常的Th 2应答。此外，骨髓来源的培养肥大细胞的分化和功能不受影响。这些结果表明，T1/ST 2在Th 2细胞和肥大细胞的发育和功能中不起重要作用。
T1/ST2, an orphan receptor with homology with the interleukin (IL)-1 receptor family, is expressed constitutively and stably on the surface of T helper type 2 (Th2) cells, but not on Th1 cells. T1/ST2 is also expressed on mast cells, which are critical for Th2-mediated effector responses. To evaluate whether T1/ST2 is required for Th2 responses and mast cell function, we have generated T1/ST2-deficient (T1/ST2−/−) mice and examined the roles of T1/ST2. Naive CD4+ T cells isolated from T1/ST2−/− mice developed to Th2 cells in response to IL-4 in vitro. T1/ST2−/− mice showed normal Th2 responses after infection with the helminthic parasite Nippostrongylus brasiliensis as well as in the mouse model of allergen-induced airway inflammation. In addition, differentiation and function of bone marrow–derived cultured mast cells were unaffected. These findings demonstrate that T1/ST2 does not play an essential role in development and function of Th2 cells and mast cells.