SYNERGY OF ABDOMINAL PRESSURE AND ANDROGENS IN TESTICULAR DESCENT
SYNERGY OF ABDOMINAL PRESSURE AND ANDROGENS IN TESTICULAR DESCENT
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DOI：
10.1095/biolreprod29.5.1233
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
RAJFER, J
中科院分区：
文献类型：
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作者：
FREY, HL;PENG, S;RAJFER, J
在大鼠中，研究了腹内压力和雄激素在促进睾丸下降方面的潜在协同活性。在老鼠身上，睾丸通常在出生后第21天左右下降。如果在14天时切除1个睾丸，并用硅胶假体取代，硅胶假体将以.apprx的形式进入阴囊。11/20(55%)的动物到28日龄。如果在14日龄时切除双侧睾丸，然后将单独的硅胶假体放入腹腔，假体将下降到阴囊内，7s4/18(22%)的动物。如果在14天时切除两个睾丸，并将硅胶假体放入腹腔，但从14天到27天每天给动物注射2毫克双氢睾酮，假体将在28天时下降到阴囊内，在接受治疗的动物中，有10/16(63%)。雄激素似乎并不是大鼠睾丸下降的唯一原因。另一种机制，如腹内压力，可能有助于这种动物的睾丸下降。在促进睾丸下降方面，雄激素和腹内压之间可能存在一定的协同作用。
The potential synergistic activity between intra-abdominal pressure and androgens in facilitating testicular descent was investigated in the rat. In the rat, the testis normally descends on or about the 21st day of age. If 1 testis is excised at 14 days of age and replaced by a silicone prosthesis, the silicone prosthesis will descend into the scrotum in .apprx. 11/20 (55%) of the animals by 28 days of age. If both testes are excised at 14 days of age and a solitary silicone prosthesis is then placed into the abdominal cavity, the prosthesis will descend into the scrotum in 7s 4/18 (22%) of the animals. If both testes are excised at 14 days of age and a silicone prosthesis is placed into the abdominal cavity but the animals are treated daily from Day 14 to Day 27 of age with 2 mg of dihydrotestosterone, the prosthesis will at 28 days of age descend into the scrotum in 10/16 (63%) of the animals treated. Androgens do not appear to be solely responsible for testicular descent in the rat. Another mechanism such as intra-abdominal pressure may be operative in facilitating testicular descent in this animal species. There may be some synergism between androgens and intra-abdominal pressure in promoting testicular descent.