Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease
Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease
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DOI：
10.1007/s10072-014-1871-9
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发表时间：
2014-12-01
影响因子：
3.3
通讯作者：
Li, Yong-Nan
中科院分区：
文献类型：
--
作者：
Zhao, Hong;Xu, Mei-Ling;Li, Yong-Nan
此前有报道称，激活的炎症细胞释放的细胞因子和神经毒素诱导黑质内多巴胺能神经元的突起丢失，从而引发PD的发病机制。本研究研究了四甲基吡嗪（TMP）对注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）小鼠旋转任务中中枢细胞因子合成、纹状体多巴胺含量和谷氨酸能传递以及行为表现的影响。TMP治疗显著改善了MPTP注射小鼠在旋转任务中的行为表现。它还降低了这些模型小鼠黑质和纹状体中细胞因子（肿瘤坏死因子- α和白细胞介素-1 β）的上调。此外，TMP治疗显著改善了MPTP小鼠纹状体多巴胺缺陷，并减轻了纹状体基底谷氨酸强度的上调。这些结果表明TMP可能是治疗PD患者的一种新方法。
It was previously reported that cytokines and neurotoxins released from activated inflammatory cells induced the loss of projecting dopaminergic neurons in the substantia nigra, which triggered the pathogenesis of PD. The present study investigated the effect of treatment with tetramethylpyrazine (TMP) on the central cytokine synthesis, striatal dopamine content and glutamatergic transmission, and behavioral performance in the rotarod task in mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Treatment with TMP significantly improved the behavioral performance in the rotarod task in mice injected with MPTP. It also decreased the upregulation of cytokines (tumor necrosis factor-alpha and interleukin-1 beta) in the substantia nigra and striatum in these modeled mice. Furthermore, treatment with TMP significantly improved the dopamine deficits and attenuated the upregulation of striatal basal glutamatergic strength in the striatum of mice injected with MPTP. These results indicated that TMP might serve as a novel approach for the treatment of patients with PD.