The effect of calcipotriol on lesional fibroblasts from patients with active morphoea.
The effect of calcipotriol on lesional fibroblasts from patients with active morphoea.
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卡泊三醇对活动性硬斑病患者病变成纤维细胞的影响。
DOI：
10.2340/000155557575364366
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发表时间：
1995
影响因子：
3.6
通讯作者：
M. Goodfield
中科院分区：
文献类型：
--
作者：
W. Bottomley;J. Jutley;E. Wood;M. Goodfield
我们研究了培养的真皮成纤维细胞的反应，从活组织检查的6例活动性morphoea和相似数量的匹配控制卡泊三醇的细胞增殖抑制活性。来自对照组的培养成纤维细胞对卡泊三醇（浓度为1 x 10（-8）至1 x 10（-4）M）无显著反应。然而，与对照组相比，在所有浓度下，卡泊三醇确实抑制了Morphoea成纤维细胞的增殖反应。与对照样品相比，在2名Morphoea患者中有4至20倍的抑制作用。其他四个morphoea样品显示出抑制，但与对照相比程度较低。
We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation response of morphoea fibroblasts at all concentrations when compared with controls. There was 4- to 20-fold inhibition in 2 of the morphoea patients when compared with control samples. Four other morphoea samples showed inhibition but to a lesser extent compared with controls.