Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.
Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.
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DOI：
10.1007/s00403-009-1001-3
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发表时间：
2010-03
影响因子：
3
通讯作者：
Katiyar SK
中科院分区：
文献类型：
--
作者：
Nichols JA;Katiyar SK
流行病学、临床和实验室研究表明，太阳紫外线辐射与各种皮肤病有关，包括皮肤过早老化以及黑色素瘤和非黑色素瘤皮肤癌。慢性紫外线辐射损伤引起的皮肤病或皮肤病是由过度诱导炎症、氧化应激和DNA损伤等引起的。使用化学预防剂，如植物多酚，以抑制这些事件在紫外线暴露的皮肤正在获得关注。化学预防是指使用可以抑制、逆转或延缓紫外线暴露皮肤中这些有害事件的过程的试剂。据报道，多种多酚或植物化学物质（其中大多数是膳食补充剂）具有显著的皮肤光保护作用。本文综述了几种多酚类化合物，如绿色茶多酚、葡萄籽原花青素、白藜芦醇、水飞蓟素和染料木黄酮对紫外线诱导的皮肤炎症、氧化应激和DNA损伤等的光保护作用。重点在于这些多酚的光保护作用的潜在机制。在动物模型中进行的实验室研究表明，这些多酚能够保护皮肤免受紫外线辐射的不利影响，包括皮肤癌的风险。这表明，多酚类物质可以有利地补充防晒保护，并可能是有用的皮肤疾病与太阳紫外线辐射诱导的炎症，氧化应激和DNA损伤。
Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including premature aging of the skin and melanoma and nonmelanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc.. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse, or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress, and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models, suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.
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