Linear growth faltering and the role of weight attainment: Prospective analysis of young children recovering from severe wasting in Niger
Linear growth faltering and the role of weight attainment: Prospective analysis of young children recovering from severe wasting in Niger
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DOI：
10.1111/mcn.12817
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发表时间：
2019-10-01
影响因子：
3.4
通讯作者：
Grais, Rebecca F.
中科院分区：
文献类型：
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作者：
Isanaka, Sheila;Hitchings, Matt D. T.;Grais, Rebecca F.
减少发育迟缓影响的努力在很大程度上独立于减少消瘦影响的干预措施，尽管观察到这两种情况可以在同一儿童身上共存，并增加死亡风险。为了优化营养不良儿童的管理，他们可能消瘦，发育不良，或两者兼而有之，发育不良和消瘦之间的关系应该得到详细说明。我们的目的是描述在严重消瘦康复期间和之后体重和身高增加之间的关系。我们对一项关于门诊治疗严重消瘦的随机试验进行了二次分析，其中包括1，542名康复并随访12周的儿童。我们描述了发育迟缓和严重消瘦的重叠以及发育迟缓随时间的变化。我们使用调整后的广义估计方程显示了同时体重和身高增加之间的关系，并计算了康复期间和康复后体重身高z评分（WHZ）和身高年龄z评分（HAZ）的平均变化率。基线时，79%（n = 1，223/1，542）和49%（n = 757/1，542）的儿童分别发育迟缓和严重发育迟缓。儿童中的患病率随着时间的推移而增加
Efforts to reduce the impact of stunting have been largely independent of interventions to reduce the impact of wasting, despite the observation that the conditions can coexist in the same child and increase risk of death. To optimize the management of malnourished children-who can be wasted, stunted, or both-the relationship between stunting and wasting should be elaborated. We aimed to describe the relationship between concurrent weight and height gain during and after rehabilitation from severe wasting. We conducted a secondary analysis of a randomized trial for the outpatient treatment of severe wasting, including 1,542 children who recovered and were followed for 12 weeks. We described the overlap of stunting and severe wasting and the change in stunting over time. We showed the relationship between concurrent weight and height gain using adjusted generalized estimating equations and calculated the mean rate of change in weight-for-height z score (WHZ) and height-for-age z score (HAZ) during and after rehabilitation. At baseline, 79% (n = 1,223/1,542) and 49% (n = 757/1,542) of children were stunted and severely stunted, respectively. Prevalence increased over time among children