Optimising the selection of outcomes for healthy ageing trials: a mixed methods study.
Optimising the selection of outcomes for healthy ageing trials: a mixed methods study.
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DOI：
10.1007/s11357-022-00690-5
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发表时间：
2022-12
期刊：
影响因子：
5.6
通讯作者：
Calvert, Melanie
中科院分区：
文献类型：
--
作者：
Syed, Muslim Abbas;Aiyegbusi, Olalekan Lee;Marston, Eliot;Lord, Janet M.;Teare, Harriet;Calvert, Melanie
老龄化与慢性病有关，而慢性病是发达国家死亡和残疾的最大原因。随着预期寿命的延长和人口的老龄化，有必要进行试验，以延长健康的老龄化，包括针对生物老化过程，并预防与老龄化有关的疾病。这项研究的主要目的如下：（i）检讨健康晚年试验的结果指标，重点是药物治疗、营养补充剂和医疗器械;（ii）总结主要持份者对健康晚年试验结果选择的意见。对Clinicaltrials.gov数据库中从开始到2022年5月的健康老龄化试验记录进行了分析。此外，还对2022年UKSPINE年度会议上主要利益攸关方参加的研讨会的结果进行了定性分析。在所评价的干预措施和纳入研究使用的结局中发现了实质性异质性。研讨会与会者认为，招募不同背景的参与者和老年人多种发病率的混杂效应是衡量健康老龄化试验结果的主要挑战。健康老龄化试验核心结果集的开发可以帮助干预措施之间和不同环境中的可比性。研讨会提供了一个重要平台，就在这一背景下衡量成果的挑战收集各种观点。至关重要的是，要启动这样的讨论，以推动这一领域的发展，并为未来如何设计和构建健康老龄化试验提供切实可行的答案。
Advancing age is associated with chronic diseases which are the largest cause of death and disability in developed countries. With increasing life expectancy and an ageing population, there is a need to conduct trials to extend healthy ageing, including targeting biological ageing processes, and prevent ageing-related diseases. The main objectives of the study are as follows: (i) to review outcome measures utilised in healthy ageing trials focusing on pharmacological therapies, nutritional supplements and medical devices; (ii) to summarise the views of key stakeholders on outcome selection for healthy ageing trials. An analysis of records from the Clinicaltrials.gov database pertaining to healthy ageing trials from inception to May 2022 was conducted. In addition, the findings of a workshop attended by key stakeholders at the 2022 annual UKSPINE conference were qualitatively analysed. Substantial heterogeneity was found in the interventions evaluated and the outcomes utilised by the included studies. Recruitment of participants with diverse backgrounds and the confounding effects of multi-morbidity in older adults were identified as the main challenges of measuring outcomes in healthy ageing trials by the workshop participants. The development of a core outcome set for healthy ageing trials can aid comparability across interventions and within different settings. The workshop provided an important platform to garner a range of perspectives on the challenges with measuring outcomes in this setting. It is critical to initiate such discussions to progress this field and provide practical answers to how healthy ageing trials are designed and structured in the future.
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DOI：
10.1093/gerona/glw149
发表时间：
2016-11
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Newman JC;Milman S;Hashmi SK;Austad SN;Kirkland JL;Halter JB;Barzilai N
通讯作者：
Barzilai N
影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
影响因子：
2.2
作者：
Maruszczyk, Konrad;Aiyegbusi, Olalekan Lee;Calvert, Melanie J.
通讯作者：
Calvert, Melanie J.
影响因子：
--
作者：
Nielsen, Johannes Leth;Bakula, Daniela;Scheibye-Knudsen, Morten
通讯作者：
Scheibye-Knudsen, Morten
影响因子：
4.5
作者：
Afshar, Sara;Roderick, Paul J.;Hill, Allan G.
通讯作者：
Hill, Allan G.