Cell adhesion molecule control of planar spindle orientation
Cell adhesion molecule control of planar spindle orientation
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DOI：
10.1007/s00018-015-2116-7
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发表时间：
2016-03
影响因子：
8
通讯作者：
Hüseyin Tuncay;K. Ebnet
中科院分区：
文献类型：
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作者：
Hüseyin Tuncay;K. Ebnet
极化的上皮细胞排列有丝分裂纺锤体在片层的平面上，以保持组织的完整性并防止恶性转化。纺锤体的定向是由侧皮质的星形微管的固定来调节的，并且依赖于动力蛋白-动力蛋白马达蛋白复合物的精确定位，该复合物捕获微管加端并产生朝向中心体的拉力。最近的发展表明，来自细胞间连接的信号是所需的动力蛋白-动力肌动蛋白复合物与皮质的稳定相互作用。在这里，我们审查的分子机制，调节平面纺锤体的方向极化上皮细胞，我们说明了不同的细胞粘附分子通过不同的和非重叠的机制，指导细胞对齐有丝分裂纺锤体在平面上的表。
Polarized epithelial cells align the mitotic spindle in the plane of the sheet to maintain tissue integrity and to prevent malignant transformation. The orientation of the spindle apparatus is regulated by the immobilization of the astral microtubules at the lateral cortex and depends on the precise localization of the dynein–dynactin motor protein complex which captures microtubule plus ends and generates pulling forces towards the centrosomes. Recent developments indicate that signals derived from intercellular junctions are required for the stable interaction of the dynein–dynactin complex with the cortex. Here, we review the molecular mechanisms that regulate planar spindle orientation in polarized epithelial cells and we illustrate how different cell adhesion molecules through distinct and non-overlapping mechanisms instruct the cells to align the mitotic spindle in the plane of the sheet.