Sonogashira couplings catalyzed by collaborative (N-heterocyclic carbene)-copper and -palladium complexes.
Sonogashira couplings catalyzed by collaborative (N-heterocyclic carbene)-copper and -palladium complexes.
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DOI：
10.1021/ol501540w
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发表时间：
2014-07
期刊：
影响因子：
5.2
通讯作者：
Christopher W. D. Gallop;Ming‐Tsz Chen;O. Navarro
中科院分区：
文献类型：
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作者：
Christopher W. D. Gallop;Ming‐Tsz Chen;O. Navarro
提出了一个用(N-杂环卡宾)-铜和(N-杂环卡宾)-Pd络合物100：1的组合进行Sonogashira反应的通用方案。催化剂负载量为1mol%(NHC)-铜和0.01mol%(NHC)-Pd时，芳基溴化物和芳基炔可以在空气和非水溶剂中高产率地偶联。
A general protocol for the Sonogashira reaction using a 100:1 combination of (N-heterocyclic carbene)-Cu and (N-heterocyclic carbene)-Pd complexes is presented. Catalyst loadings of 1 mol % (NHC)-Cu and 0.01 mol % (NHC)-Pd allow for the coupling of aryl bromides and aryl alkynes, in air and in a non-anhydrous solvent, in high yields.