EAST-COAST FEVER PART 1 CHEMO PROPHYLACTIC IMMUNIZATION OF CATTLE AGAINST THEILERIA-PARVA MUGUGA AND 5 THEILERIAL STRAINS
EAST-COAST FEVER PART 1 CHEMO PROPHYLACTIC IMMUNIZATION OF CATTLE AGAINST THEILERIA-PARVA MUGUGA AND 5 THEILERIAL STRAINS
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DOI：
10.1016/0304-4017(75)90005-9
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发表时间：
1975-01-01
影响因子：
2.6
通讯作者：
YOUNG A S
中科院分区：
文献类型：
--
作者：
RADLEY D E;BROWN C G D;YOUNG A S
在一项试验中，采用化学预防或治疗方法对牛群进行了抗T。parva（Muguga），并用5种最近分离的泰勒虫株进行攻击。其中2株在免疫动物中引起轻度或不明显反应，3株引起显著反应。25只免疫动物在攻毒时均未死亡; 25只易感（未免疫）动物中有22只死亡。在第二次实验中，使用化学预防法对牛组进行5种田间菌株免疫。它们的免疫反应很小，对同种异体免疫和随后的T. parva（Muguga）.这表明，牛可以通过用1 ml适当菌株的感染稳定剂接种，并从感染当天开始连续4天每天同时接种5 mg/kg土霉素制剂，有效免疫几种泰勒虫菌株的致死性攻毒。T. parva（Muguga）可能是东非多价东海岸热（ECF）疫苗的有价值的组分。
In 1 experiment, groups of cattle were immunized using chemoprophylaxis or therapy against T. parva (Muguga), and were challenged with 5 recently-isolated strains of Theileria. Two of the strains caused mild or inapparent reactions in the immunized animals, and 3 caused significant reactions. None of 25 immunized animals died on challenge; 22 of 25 susceptible (non-immunized) animals died. In a 2nd experiment, groups of cattle were immunized against 5 field strains using chemoprophylaxis. They had minimal reactions and were solidly immune to isologous challenge and to subsequent challenge with T. parva (Muguga). This demonstrated that cattle could be effectively immunized against lethal challenge with several theilerial strains by inoculating them with 1 ml of an infective stabilate of the appropriate strain and the concomitant daily inoculation of 5 mg/kg of a formulation of oxytetracycline on 4 consecutive days starting on the day of infection. T. parva (Muguga) may be a valuable component of a polyvalent East Coast fever (ECF) vaccine in E Africa.