Synthesis of P-chiral phosphine compounds by palladium-catalyzed C-P coupling reactions
Synthesis of P-chiral phosphine compounds by palladium-catalyzed C-P coupling reactions
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钯催化C-P偶联反应合成P-手性膦化合物
DOI：
10.1039/d0cc05340f
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发表时间：
2020
影响因子：
4.9
通讯作者：
Che Chi-Ming
中科院分区：
文献类型：
--
作者：
Wang Cuiying;Yue Chang-Duo;Yuan Jia;Zheng Jia-Lian;Zhang Ying;Yu Hong;Chen Jian;Meng Sixuan;Yu Yang;Yu Guang-Ao;Che Chi-Ming
使用 Pd(OAc)2/dppf 作为催化剂，开发了对映纯叔丁基甲基膦硼烷与芳基和杂芳基卤化物的高效 C-P 偶联反应，以中等到高收率提供一系列 (S) 或 (R)-P-手性膦，ee 值高达 99% ee。此外，随着微波辐射下ee值的增加，反应时间可以从72小时减少到6小时。
An efficient C–P coupling reaction of enantiopure tert-butylmethylphosphine-boranes with aryl and heteroaryl halides is developed by using Pd(OAc)2/dppf as a catalyst, affording a series of (S) or (R)-P-chiral phosphines in moderate to high yields and with ee values up to 99% ee. Moreover, the reaction time could be reduced from 72 h to 6 h with increased ee values under microwave irradiation.