Leukaemia: Fusion cooking
Leukaemia: Fusion cooking
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DOI：
10.1038/nrc1603
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发表时间：
2005-04
影响因子：
78.5
通讯作者：
Jun Zhu;Jun Zhou;L. Pérès;Florence Riaucoux;N. Honoré;S. Kogan;H. de Thé
中科院分区：
文献类型：
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作者：
Jun Zhu;Jun Zhou;L. Pérès;Florence Riaucoux;N. Honoré;S. Kogan;H. de Thé
通过定量聚合酶链反应和荧光原位杂交检测了接受男性肾脏移植的女性患者的皮肤肿瘤。在许多情况下检测到雄性细胞。一种特定的癌细胞显示出雄性细胞的模式，似乎是由单个供体细胞的克隆扩增产生的。因此，来自移植器官的干细胞可能迁移到皮肤，分化成角质形成细胞或与角质形成细胞融合，然后很少发生肿瘤转化。
Cutaneous tumours arising in female patients who had received a male kidney were examined by quantitative polymerase chain reaction and fluorescence in situ hybridization. Male cells were detected in many cases. A particular carcinoma showed a pattern of male cells that seemed to have arisen from the clonal expansion of a single donor cell. So, stem cells from a grafted organ might migrate to the skin, differentiate into, or fuse with, keratinocytes and then, rarely, undergo neoplastic transformation.