Differential diagnosis of lipoma‐like lipoblastoma
Differential diagnosis of lipoma‐like lipoblastoma
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脂肪瘤样脂肪母细胞瘤的鉴别诊断
DOI：
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发表时间：
2009
影响因子：
3.2
通讯作者：
C. Panarello
中科院分区：
文献类型：
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作者：
C. Morerio;P. Nozza;E. Tassano;C. Rosanda;C. Granata;M. Conte;C. Panarello
脂肪母细胞瘤是一种罕见的白色脂肪组织良性肿瘤，主要发生在幼儿。偶尔，形态学表现的异质性和与其他脂肪生成性肿瘤的组织学重叠被描述。在这种情况下，荧光原位杂交（FISH）分析PLAG 1，一个基因在脂肪母细胞瘤特异性重排，是必要的，以防止误诊。我们提出一个病例脂肪母细胞瘤发生在一个不典型的网站与脂肪瘤的组织学特征。通过鉴定特征性PLAG 1-HAS 2融合基因，在细胞遗传学基础上做出正确诊断，从而允许适当的临床方法。儿科血液癌症2009;52：132-134.© 2008 Wiley利斯公司
Lipoblastomas are rare benign tumors of white fatty tissue that occur primarily in young children. Occasionally, heterogeneity of morphological appearance and histological overlap with other lipogenic tumors are described. In such cases fluorescence in situ hybridization (FISH) analysis of PLAG1, a gene specifically rearranged in lipoblastoma, is necessary to prevent misdiagnosis. We present a case of lipoblastoma arising in an atypical site with histological features characteristic of lipoma. The correct diagnosis was made possible on cytogenetic grounds through the identification of the characteristic PLAG1‐HAS2 fusion gene, thus allowing an appropriate clinical approach. Pediatr Blood Cancer 2009;52:132–134. © 2008 Wiley‐Liss, Inc.