EFFECTS OF AGE ON ENDOTHELIUM-DEPENDENT VASODILATION OF RESISTANCE CORONARY-ARTERY BY ACETYLCHOLINE IN HUMANS
EFFECTS OF AGE ON ENDOTHELIUM-DEPENDENT VASODILATION OF RESISTANCE CORONARY-ARTERY BY ACETYLCHOLINE IN HUMANS
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DOI：
10.1161/01.cir.88.1.77
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发表时间：
1993-07-01
期刊：
影响因子：
37.8
通讯作者：
TAKESHITA, A
中科院分区：
文献类型：
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作者：
EGASHIRA, K;INOU, T;TAKESHITA, A
背景研究表明，内皮相关的血管运动在冠状动脉循环的控制中起重要作用。我们的目标是确定18例冠状动脉血管造影正常且无冠状动脉危险因素的非典型胸痛患者（年龄23-70岁）的冠状动脉血管内皮依赖性舒张功能是否随年龄增长而改变。我们将内皮依赖性血管扩张剂乙酰胆碱（1、3、10和30 μ g/min）和内皮非依赖性血管扩张剂罂粟碱（10 mg）注入左冠状动脉。通过动脉造影评估大冠状动脉直径，并使用冠状动脉内多普勒导管技术测量冠状动脉血流量的增加。乙酰胆碱以剂量依赖性方式增加冠状动脉血流量，动脉压和心率无变化。乙酰胆碱引起的冠状动脉血流量最大增加在不同患者之间差异很大（冠状动脉血流量增加范围为200%至560%），并与年龄显著相关（r=-.86，P
Background. It has been suggested that endothelium-related vasomotion is important in the control of coronary circulation. Our goal was to determine if endothelium-dependent dilation of the coronary vasculature was altered with aging in 18 patients with atypical chest pain (age, 23-70 years) who had angiographically normal coronary arteries and no coronary risk factors.Methods and Results. We infused an endothelium-dependent vasodilator acetylcholine (1, 3, 10, and 30 mug/min) and an endothelium-independent vasodilator papaverine (10 mg) into the left coronary artery. The large coronary diameter was assessed by arteriography, and the increase in coronary blood flow was measured using the intracoronary Doppler catheter technique. Acetylcholine increased coronary blood flow in a dose-dependent manner with no changes in arterial pressure and heart rate. The maximum increase in coronary blood flow evoked by acetylcholine varied widely among patients (increase in coronary blood flow ranged from 200% to 560%) and was correlated significantly with aging (r=-.86, P