CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion
CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion
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DOI：
10.1182/blood.2020009482
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发表时间：
2021-06-10
期刊：
影响因子：
20.3
通讯作者：
Muenz, Christian
中科院分区：
文献类型：
--
作者：
Deng, Yun;Chatterjee, Bithi;Muenz, Christian
共刺激分子CD27及其配体CD70中的原发性免疫缺陷使几乎所有受影响的患者易于发生不受控制的EB病毒（EBV）感染的病理。我们证明，CD27（+）细胞的耗竭和抗体阻断CD27与CD70的相互作用，导致重建的人类免疫系统成分的小鼠不受控制的EBV感染。虽然在抗体阻断CD27后，总体CD8（+）T细胞扩增和组成没有改变，但只有一些EBV特异性CD8（+）T细胞应答，例如早期裂解性EBV抗原BMLF1特异性CD8（+）T细胞，在其增殖和杀死EBV转化的B细胞方面受到抑制。这表明，CD27不是所有CD8（+）T细胞扩增和细胞毒性所必需的，而是保护我们免受EBV病理的CD8（+）T细胞应答子集所必需的。
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27(+) cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8(+) T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8(+) T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8(+) T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8(+) T-cell expansions and cytotoxicity but is required for a subset of CD8(+) T-cell responses that protect us from EBV pathology.