CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.
CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.
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DOI：
10.4049/jimmunol.147.8.2461
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发表时间：
1991-10
影响因子：
4.4
通讯作者：
M. Jenkins;P. Taylor;S. Norton;K. Urdahl
中科院分区：
文献类型：
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作者：
M. Jenkins;P. Taylor;S. Norton;K. Urdahl
CD 4 + T细胞需要两种信号来产生最大量的IL-2，即，TCR占有率和未鉴定的APC衍生的共刺激。在这里，我们表明，这种共刺激信号可以通过T细胞分子CD 28传递。激动性抗CD 28 mAb，而不是IL-1和/或IL-6，刺激破伤风类毒素特异性T细胞与Ag脉冲，共刺激缺陷型APC培养的T细胞增殖。此外，B细胞肿瘤系向纯化的T细胞提供共刺激信号的能力与CD 28配体B7/BB-1的表达密切相关。最后，与抗CD 28 mAb一样，自体人APC似乎刺激T细胞活化的环孢霉素A抗性途径。总之，这些结果表明，由CD 4 + T细胞产生IL-2所需的两种信号可以由TCR和CD 28转导。
CD4+ T cells require two signals to produce maximal amounts of IL-2, i.e., TCR occupancy and an unidentified APC-derived costimulus. Here we show that this costimulatory signal can be delivered by the T cell molecule CD28. An agonistic anti-CD28 mAb, but not IL-1 and/or IL-6, stimulated T cell proliferation by tetanus toxoid-specific T cells cultured with Ag-pulsed, costimulation-deficient APC. Furthermore, the ability of B cell tumor lines to provide costimulatory signals to purified T cells correlated well with expression of the CD28 ligand B7/BB-1. Finally, like anti-CD28 mAb, autologous human APC appeared to stimulate a cyclosporine A-resistant pathway of T cell activation. Together, these results suggest that the two signals required for IL-2 production by CD4+ T cells can be transduced by the TCR and CD28.