Stable population structure in Europe since the Iron Age, despite high mobility.
Stable population structure in Europe since the Iron Age, despite high mobility.
复制标题
欧洲自铁器时代以来的稳定人口结构，尽管流动性很高。
DOI：
10.7554/elife.79714
复制
发表时间：
2024-01-30
期刊：
影响因子：
7.7
通讯作者：
Pritchard JK
中科院分区：
文献类型：
--
作者：
Antonio ML;Weiß CL;Gao Z;Sawyer S;Oberreiter V;Moots HM;Spence JP;Cheronet O;Zagorc B;Praxmarer E;Özdoğan KT;Demetz L;Gelabert P;Fernandes D;Lucci M;Alihodžić T;Amrani S;Avetisyan P;Baillif-Ducros C;Bedić Ž;Bertrand A;Bilić M;Bondioli L;Borówka P;Botte E;Burmaz J;Bužanić D;Candilio F;Cvetko M;De Angelis D;Drnić I;Elschek K;Fantar M;Gaspari A;Gasperetti G;Genchi F;Golubović S;Hukeľová Z;Jankauskas R;Vučković KJ;Jeremić G;Kaić I;Kazek K;Khachatryan H;Khudaverdyan A;Kirchengast S;Korać M;Kozlowski V;Krošláková M;Kušan Špalj D;La Pastina F;Laguardia M;Legrand S;Leleković T;Leskovar T;Lorkiewicz W;Los D;Silva AM;Masaryk R;Matijević V;Cherifi YMS;Meyer N;Mikić I;Miladinović-Radmilović N;Milošević Zakić B;Nacouzi L;Natuniewicz-Sekuła M;Nava A;Neugebauer-Maresch C;Nováček J;Osterholtz A;Paige J;Paraman L;Pieri D;Pieta K;Pop-Lazić S;Ruttkay M;Sanader M;Sołtysiak A;Sperduti A;Stankovic Pesterac T;Teschler-Nicola M;Teul I;Tončinić D;Trapp J;Vulović D;Waliszewski T;Walter D;Živanović M;Filah MEM;Čaušević-Bully M;Šlaus M;Borić D;Novak M;Coppa A;Pinhasi R;Pritchard JK
过去十年的古代DNA研究表明，欧洲人口结构在史前时期（距今14000 -3000年，YBP）发生了巨大变化，反映了新石器时代农民和青铜时代草原祖先的广泛引入。然而，很少有人知道人口结构如何从历史时期（3000 YBP -现在）的变化。为了解决这个问题，我们收集了来自欧洲和地中海的204个个体的全基因组，其中许多是来自他们地区（例如亚美尼亚和法国）的第一个历史时期的基因组。我们发现，大多数地区表现出显着的个体间异质性。至少有7%的历史上的个人携带的祖先在他们被抽样的地区不常见，一些人表明跨地中海接触。尽管人口流动性很高，但欧亚大陆西部的总体人口结构在历史时期到目前为止相对稳定，反映了地理位置。我们表明，在标准的人口遗传学模型与本地panmixia，所观察到的扩散水平将导致人口结构的崩溃。因此，持久的人口结构表明一个较低的有效迁移率比所观察到的分散。我们假设，这一现象可以解释为广泛的短暂分散所产生的急剧改善的交通网络和罗马帝国的贸易，劳动和军事动员的人。这项工作突出了古代DNA在阐明近代历史上更精细的人口动态方面的效用。
Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000–3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.g. Armenia and France). We found that most regions show remarkable inter-individual heterogeneity. At least 7% of historical individuals carry ancestry uncommon in the region where they were sampled, some indicating cross-Mediterranean contacts. Despite this high level of mobility, overall population structure across western Eurasia is relatively stable through the historical period up to the present, mirroring geography. We show that, under standard population genetics models with local panmixia, the observed level of dispersal would lead to a collapse of population structure. Persistent population structure thus suggests a lower effective migration rate than indicated by the observed dispersal. We hypothesize that this phenomenon can be explained by extensive transient dispersal arising from drastically improved transportation networks and the Roman Empire’s mobilization of people for trade, labor, and military. This work highlights the utility of ancient DNA in elucidating finer scale human population dynamics in recent history.