Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
复制标题
Picornavirus，Norovirus和冠状病毒的3C和3C样蛋白酶的大环抑制剂。
DOI：
10.1016/j.bmcl.2013.05.021
复制
发表时间：
2013-07-01
影响因子：
2.7
通讯作者：
Groutas, William C.
中科院分区：
文献类型：
--
作者：
Mandadapu, Sivakoteswara Rao;Weerawarna, Pathum M.;Prior, Allan M.;Uy, Roxanne Adeline Z.;Aravapalli, Sridhar;Alliston, Kevin R.;Lushington, Gerald H.;Kim, Yunjeong;Hua, Duy H.;Chang, Kyeong-Ok;Groutas, William C.
The design, synthesis, and in vitro inhibitory activity of the first series of macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus, are reported. The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.
登录
查看更多内容
影响因子：
2.7
作者：
Dou, Dengfeng;He, Guijia;Groutas, William C.
通讯作者：
Groutas, William C.
影响因子：
64.8
作者：
ALLAIRE, M;CHERNAIA, MM;JAMES, MNG
通讯作者：
JAMES, MNG
影响因子：
5
作者：
Hardy, ME;Crone, TJ;Ettayebi, K
通讯作者：
Ettayebi, K
影响因子：
3.7
作者：
Chuck CP;Chow HF;Wan DC;Wong KB
通讯作者：
Wong KB
影响因子：
3.7
作者：
Blakeney, SJ;Cahill, A;Reilly, PA
通讯作者：
Reilly, PA