A mouse model of depression induced by repeated corticosterone injections.
A mouse model of depression induced by repeated corticosterone injections.
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DOI：
10.1016/j.ejphar.2007.12.005
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发表时间：
2008-02
影响因子：
5
通讯作者：
Yunan Zhao;Ru Ma;Jia Shen;Hui Su;Dongming Xing;L. Du
中科院分区：
文献类型：
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作者：
Yunan Zhao;Ru Ma;Jia Shen;Hui Su;Dongming Xing;L. Du
最近，通过外源性皮质酮给药建立了大鼠抑郁症模型。在这项研究中，我们进一步确定了皮质酮管理是否也增加了抑郁样行为的小鼠，并探讨了暴露于这种管理模式的脑生化后果。小鼠重复注射溶剂和20 mg/kg皮质酮1、3和5周，然后进行强迫游泳和悬尾试验。结果表明，重复注射皮质酮以时间依赖的方式增加强迫游泳和悬尾试验中的不动行为。同时，这种注射模式对小鼠海马中的酪氨酸羟化酶（TH）水平产生了与时间相关的影响。这些结果与应激诱导的抑郁模型中的相关性一致，并表明重复皮质酮注射范例提供了一个有用和可靠的小鼠模型，在该模型中进一步研究应激和糖皮质激素在抑郁症中的作用，以及筛选抗抑郁药或预防药物。
A rat model of depression has been recently developed by exogenous corticosterone administration. In this study, we further determined whether corticosterone administration also increased depression-like behavior in mice and explored the brain biochemical consequences of exposure to this administration paradigm. Mice received repeated injections of vehicle and 20 mg/kg of corticosterone for 1, 3 and 5 weeks, and then were subjected to the forced-swim and tail suspension tests. The results showed that repeated corticosterone injections increased immobility behavior in the forced-swim and tail suspension tests in a time-dependent manner. Meanwhile, this injection paradigm produced a time-related effect on tyrosine hydroxylase (TH) levels in the hippocampus of mice. These results are consistent with correlations in stress-induced depression models, and suggest that the repeated corticosterone injection paradigm provides a useful and reliable mouse model within which to further study the role of stress and glucocorticoids in depressive illness, as well as screen for antidepressants or preventive drugs.