ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
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DOI：
10.1182/blood-2006-07-038166
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发表时间：
2007-03-01
期刊：
影响因子：
20.3
通讯作者：
Rosendaal, Frits R.
中科院分区：
文献类型：
--
作者：
Chion, Chan K. N. K.;Doggen, Carine J. M.;Rosendaal, Frits R.
血管性假血友病因子(von Willebrand factor，VWF)在血管损伤部位介导了血小板的拴系/粘连。该功能取决于其由ADAMTS13控制的多位数大小。在一项基于人群的病例对照研究(Leiden[SMILE]研究)中，我们用酶联免疫吸附分析(EL ISA)检测了血浆ADAMTS13和VWF抗原水平，该研究包括560名首次心肌梗死(MI)男性和646名对照受试者。虽然ABO血型影响VWF水平，但对ADAMTS13没有影响。此外，血浆ADAMTS13水平与VWF水平无相关性。与VWF相似，ADAMTS13的每四分位数与最低四分位数(优势比，1.5-1.6)相比，MI的估计风险增加。如果得到证实，ADAMTS13与MI的关联可能暗示ADAMTS13的一种意想不到的机械作用。
Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13.