Extramedullary plasmacytoma: A form of marginal zone cell lymphoma?
Extramedullary plasmacytoma: A form of marginal zone cell lymphoma?
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髓外浆细胞瘤：边缘区细胞淋巴瘤的一种形式？
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
G. Frizzera
中科院分区：
文献类型：
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作者：
J. Hussong;S. Perkins;B. Schnitzer;H. Hargreaves;G. Frizzera
髓外浆细胞瘤（EMP）、骨孤立性浆细胞瘤和多发性骨髓瘤是相关的肿瘤，但EMP显然是一个不同的实体。此外，EMP和边缘区B细胞淋巴瘤（MZLs）之间存在组织学和临床相似性，显示广泛的浆细胞分化，这表明可能存在组织发生关系。对5例浆细胞广泛分化的EMP的组织学和临床特征进行了组织学分析，以了解MZL的特征。还回顾了2例患者先前诊断的粘膜相关淋巴组织（MALT）型MZL。所有患者均为48 - 79岁的女性。电磁脉冲起源于腮腺、淋巴结、硬脑膜或小肠。最初诊断为MALT型MZL的肿瘤位于肺和小肠。所有患者均行切除术，伴或不伴放射治疗。1例患者还接受了全身化疗。所有患者均存活，无疾病证据。所有肿瘤均含有大量浆细胞，占淋巴样细胞的55%至90%。中心细胞样细胞和单核细胞样B细胞各占浸润的0%至25%。在所有肿瘤的上皮存在部位均观察到上皮性病变。所有肿瘤均可见反应性滤泡。EMP可能代表已经经历了广泛程度的浆细胞分化的MZL。
Extramedullary plasmacytoma (EMP), solitary plasmacytoma of bone, and multiple myeloma are related neoplasms, but EMP is clearly a distinct entity. Moreover, there are histologic and clinical similarities between EMP and marginal zone B-cell lymphomas (MZLs) displaying extensive plasma cell differentiation, suggesting a possible histogenetic relationship. The histologic and clinical features of 5 EMPs with extensive plasma cell differentiation were histologically reviewed for features of MZL. The previously diagnosed MZLs, mucosa-associated lymphoid tissue (MALT) type, of 2 patients also were reviewed. All patients were women aged 48 to 79 years. The EMPs originated in the parotid gland, lymph nodes, dura, or small bowel. The initial tumors diagnosed as MALT-type MZL were located in the lung and small bowel. All patients were treated with resection, with or without irradiation therapy. One patient also received systemic chemotherapy. All patients are alive with no evidence of disease. All tumors contained large numbers of plasma cells, constituting between 55% and 90% of the lymphoid cells. Centrocyte-like cells and monocytoid B cells each represented 0% to 25% of the infiltrate. Lymphoepithelial lesions were observed in all of the tumors in sites where epithelium was present. Reactive follicles were found in all of the tumors. EMPs may represent MZLs that have undergone an extensive degree of plasmacytic differentiation.