Complexity and diversity of hepatitis C virus RNA in african americans and whites: analysis of the envelope-coding domain.
Complexity and diversity of hepatitis C virus RNA in african americans and whites: analysis of the envelope-coding domain.
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非裔美国人和白人丙型肝炎病毒 RNA 的复杂性和多样性：包膜编码域分析。
DOI：
10.1086/421506
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sherman,KennethE
中科院分区：
文献类型：
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作者：
Keenan,EricaD;Rouster,SusanD;Shire,NorahJ;Horn,PaulS;Sherman,KennethE
感染丙型肝炎病毒（HCV）的非裔美国人对干扰素治疗的反应性低于白人。准物种的复杂性和多样性进行了评估，在匹配的非洲裔美国人和白色个人。第一高变区的复杂性和多样性在两组中相似。在来自白色患者的克隆中，非同义氨基酸置换的频率和非同义突变与同义突变的平均比率都更高。在其他保守的位置上观察到氨基酸使用的种族差异。在关键位置的氨基酸代表性的差异是暗示免疫和功能选择沿着种族线。
African Americans infected with hepatitis C virus (HCV) are less responsive than whites to interferon-based therapy.HCV quasi species have been implicated. Quasi-species complexity and diversity were evaluated in matched African American and white individuals. Complexity and diversity in the first hypervariable region were similar in the 2 groups. Both the frequency of nonsynonymous amino acid substitutions and the mean ratio of nonsynonymous mutations to synonymous mutations were greater in clones derived from white patients. Racial differences in amino acid usage at otherwise conserved positions were observed. Differences in amino acid representation at key positions are suggestive of immunologic and functional selection along racial lines.