Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing.
Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing.
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DOI：
10.4161/rna.22706
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发表时间：
2013-01
期刊：
影响因子：
4.1
通讯作者：
Pyle AM
中科院分区：
文献类型：
--
作者：
Luo D;Kohlway A;Pyle AM
双链RNA是生命系统中一类重要的功能大分子。它们通常被发现是高度专业化的细胞内机器的一部分，控制不同的细胞事件，从病毒复制、抗病毒防御、RNA干扰到基因活动和基因组完整性的调节。在不同的细胞内机器中，RNA双链体通常与特定的RNA依赖性ATP酶（包括Dicer、RIG-I和DRH-3蛋白）相关。这些双链体RNA激活的ATP酶代表了大型且多样的超家族2核酸依赖性ATP酶（其历史上被定义为SF 2解旋酶）内的一组新兴的马达蛋白。双链体RNA激活的ATP酶共有双链体RNA识别的特征性分子特征，包括基序（例如，基序IIa和Vc）和插入结构域（HEL 2 i），并且它们需要双链RNA结合以实现其酶活性。该家族中的蛋白质经历伴随RNA结合、ATP结合和ATP水解的大的构象变化，以实现其功能，包括释放信号结构域和募集伴侣蛋白。双链体RNA激活的ATP酶代表了一组独特而迷人的纳米机械分子马达，这些马达对于双链体RNA在不同细胞途径中的传感和加工至关重要。
Double-stranded RNAs are an important class of functional macromolecules in living systems. They are usually found as part of highly specialized intracellular machines that control diverse cellular events, ranging from virus replication, antiviral defense, RNA interference, to regulation of gene activities and genomic integrity. Within different intracellular machines, the RNA duplex is often found in association with specific RNA-dependent ATPases, including Dicer, RIG-I and DRH-3 proteins. These duplex RNA-activated ATPases represent an emerging group of motor proteins within the large and diverse super family 2 nucleic acid-dependent ATPases (which are historically defined as SF2 helicases). The duplex RNA-activated ATPases share characteristic molecular features for duplex RNA recognition, including motifs (e.g., motifs IIa and Vc) and an insertion domain (HEL2i), and they require double-strand RNA binding for their enzymatic activities. Proteins in this family undergo large conformational changes concomitant with RNA binding, ATP binding and ATP hydrolysis in order to achieve their functions, which include the release of signaling domains and the recruitment of partner proteins. The duplex RNA-activated ATPases represent a distinct and fascinating group of nanomechanical molecular motors that are essential for duplex RNA sensing and processing in diverse cellular pathways.
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DOI：
10.1074/jbc.c900018200
发表时间：
2009-04-17
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Collins R;Karlberg T;Lehtiö L;Schütz P;van den Berg S;Dahlgren LG;Hammarström M;Weigelt J;Schüler H
通讯作者：
Schüler H
影响因子：
3.9
作者：
Foulkes, William D.;Bahubeshi, Amin;Priest, John R.
通讯作者：
Priest, John R.
影响因子：
4.8
作者：
Bamming, Darja;Horvath, Curt M.
通讯作者：
Horvath, Curt M.
影响因子：
6.8
作者：
GORBALENYA, AE;KOONIN, EV
通讯作者：
KOONIN, EV
影响因子：
16.8
作者：
Buettner, Katharina;Nehring, Sebastian;Hopfner, Karl-Peter
通讯作者：
Hopfner, Karl-Peter