Experiments on the growth of blood vessels in thin tissue and in small autografts
Experiments on the growth of blood vessels in thin tissue and in small autografts
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薄组织和小型自体移植物中血管生长的实验
DOI：
10.1002/ar.1091330302
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发表时间：
1959
期刊：
影响因子：
--
通讯作者：
Roy G. Williams
中科院分区：
文献类型：
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作者：
Roy G. Williams
内皮细胞和血管形成的生长特性在许多物种中是相似的。如在活的两栖动物幼虫和哺乳动物中所见，毛细血管由先前存在的毛细血管和微静脉通过固体上皮芽形成，所述固体上皮芽变成管道化的（Clark和Clark，'39）。Chalkley、Algirc和Morris（'46）在小鼠中观察到，在看到血管萌芽之前，愈合伤口中的血管化水平增加多达49%。因此，除了毛细血管发芽之外，可能还有一种尚未明确定义的手段用于延伸形成的血管丛。在自体移植物的血管化过程中，如在使用腔室方法的兔中所见，毛细血管通过固体内皮芽的管道化生长，并且在某些条件下，通过大毛细血管和血窦的囊状形成生长，如下文所述。在透明腔中长期存活的小的自体移植物的血管供应类似于供体部分。移植物血管化的第一阶段的某些方面可以通过移植到不同年龄的腔室中而改变。这些变化以及薄组织和血管对显微损伤的反应是本研究的主要课题。
Growth properties of endothelium and vessel formation are similar in a wide range of species. As seen in living amphibian larvae and mammals, blood capillaries form from preexisting capillaries and venules by solid eiidothelial sprouts which become canalized (Clark and Clark, '39). Chalkley, Algirc and Morris ('46) observed in mice that the level of vascularization in a healing wound increased by as much as 49% before vascular sprouts were seen. Thus, there may be a means, not yet clearly defined, for extension of a formed vascular plexus in addition to capillary sprouting. During vascularization of autografts, as seen in rabbits with chamber methods, capillaries grow by canalization of solid endothelial sprouts and also, under certain conditions, by sacculation from large capillaries and sinusoids as will be explained hereafter. The vascular supply of small autografts surviving for long periods in transparent chambers in rabbits resembles that of the donor part. Some aspects of the first stages of vascularization of grafts can be varied by grafting into chambers of various ages. These variations and thin tissue and vascular response to microscopic injury are the chief subjects of this