No evidence from complementary data sources of a direct projection from the mouse anterior cingulate cortex to the hippocampal formation
No evidence from complementary data sources of a direct projection from the mouse anterior cingulate cortex to the hippocampal formation
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DOI：
10.1101/2022.01.25.477805
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
L. Andrianova;Steliana Yanakieva;Gabriella Margetts-Smith;S. Kohli;Erica S Brady;J. Aggleton;Michael T Craig
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文献类型：
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作者：
L. Andrianova;Steliana Yanakieva;Gabriella Margetts-Smith;S. Kohli;Erica S Brady;J. Aggleton;Michael T Craig
前额皮质和海马体之间的连通性和相互作用支撑了许多关键的认知过程，这些相互作用的变化在神经发育和神经退行性疾病中都有牵连。因此，了解这种神经回路所通过的精确的细胞连接，对于理解这些相同的过程至关重要。最近的一项研究推翻了早期的发现，描述了从前扣带皮层到海马体的一种新的兴奋性投射。我们试图通过多种互补方法验证这一意外发现：顺行和逆行解剖示踪，使用顺行和逆行aav和单突触狂犬病示踪。此外，我们对Allen投影脑图谱数据库进行了广泛的数据搜索，以在任何沉积的解剖研究中找到所述的投影，作为我们自己结果的独立验证。然而，我们没有发现任何证据表明从小鼠前扣带皮层到海马体有直接的单突触投射。
The connectivity and interplay between the prefrontal cortex and hippocampus underpin a number of key cognitive processes, with changes in these interactions being implicated in both neurodevelopmental as well as neurodegenerative conditions. Understanding the precise cellular connections through which this circuit is organised is, therefore, vital for understanding these same processes. Overturning earlier findings, a recent study described a novel excitatory projection from anterior cingulate cortex to hippocampus. We sought to validate this unexpected finding using multiple, complementary methods: anterograde and retrograde anatomical tracing, using both anterograde and retrograde AAVs and monosynaptic rabies tracing. Additionally, an extensive data search of the Allen Projection Brain Atlas database was conducted to find the stated projection within any of the deposited anatomical studies, as an independent verification of our own results. However, we failed to find any evidence of a direct, monosynaptic projection from mouse anterior cingulate cortex to the hippocampus proper.