Present status of renal cell carcinoma in dialysis patients in Japan: Questionnaire study in 2002
Present status of renal cell carcinoma in dialysis patients in Japan: Questionnaire study in 2002
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DOI：
10.1159/000077590
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Ishikawa, I
中科院分区：
文献类型：
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作者：
Ishikawa, I
目的：为了确定透析患者肾细胞癌 (RCC) 的发病率和近期趋势，日本进行了一项全国范围的调查。方法：2002 年 2 月，向日本的透析单位发放了 3,155 份调查问卷。研究的变量包括 2000 年 3 月至 2002 年 2 月期间诊断的肾细胞癌，包括患者年龄、透析持续时间、诊断辅助工具、癌症大小、癌症组织学以及是否存在转移和获得性囊肿。结果：对 489 例 RCC（381 例男性、104 例女性和 4 例未知）进行了研究。 RCC患者的平均年龄为57.5+/-11.4（平均值+/-SD）岁，平均透析时间为136.9+/-95.2个月。 5.3% 的病例仅通过症状发现肾细胞癌，46.1% 的病例通过超声筛查发现，44.2% 的病例通过计算机断层扫描筛查发现。转移率为15.2%。男性透析患者的标准化发病率为 9.7（95% 置信区间，CI：8.3-11.2），女性透析患者的标准化发病率为 11.0（95% CI：8.2-14.4）。与 215 名透析时间少于 10 年的患者相比，84 名血液透析超过 20 年的 RCC 患者更年轻，男性居多，且癌症体积更大，乳头状 RCC 发生率更高，转移率更高，致死性 RCC 发生率更高。结论：54.6%的RCC患者接受透析时间超过10年。透析时间超过20年的RCC患者，平均年龄较透析时间小于10年的RCC患者年轻，且转移率较高。版权所有 (C) 2004 S. Karger AG，巴塞尔。
Aims: To determine the incidence and recent trends of renal cell carcinoma (RCC) in dialysis patients, a nationwide investigation was performed in Japan. Methods: In February 2002, 3,155 questionnaires were sent to dialysis units in Japan. The variables studied for RCC diagnosed between March 2000 and February 2002 included patient age, duration of dialysis, diagnostic aids, cancer size, histology of cancer, and the presence of metastasis and acquired cysts. Results: 489 RCCs (381 males, 104 females, and 4 unknown) were studied. The mean age of the RCC patients was 57.5+/-11.4 (mean+/-SD) years, and the mean duration of dialysis was 136.9+/-95.2 months. RCC was detected by symptoms alone in 5.3% of the cases, by sonographic screening in 46.1%, and computed tomographic screening in 44.2%. The metastasis rate was 15.2%. The standardized incidence ratio was 9.7 (95% confidence interval, CI: 8.3-11.2) for the male dialysis patients and 11.0 ( 95% CI: 8.2-14.4) for the female patients. Eighty-four of the RCC patients with more than 20 years of hemodialysis were younger, were more frequently male, and demonstrated a larger cancer size, a higher incidence of papillary RCC, a higher metastasis rate, and a higher incidence of fatal RCC than 215 patients with less than 10 years of dialysis. Conclusion: 54.6% of the patients with RCC received dialysis for more than 10 years. For RCC patients with more than 20 years of dialysis, the mean age was younger, and the metastasis rate was higher than for RCC patients with less than 10 years of dialysis. Copyright (C) 2004 S. Karger AG, Basel.