Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model
Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model
复制标题
通过混合状态模型将载体形态与干粉吸入器用粘合剂混合物的粉末力学联系起来
DOI：
10.1016/j.ijpharm.2019.02.038
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发表时间：
2019-04-20
影响因子：
5.8
通讯作者：
Alderborn, Goran
中科院分区：
文献类型：
--
作者：
Ruden, Jonas;Frenning, Goran;Alderborn, Goran
本研究的目的是调查载体形态如何影响粘合剂混合物中的共混状态的表达作为表面覆盖率（SCR）的函数，并确定不同状态之间的转换发生在哪里。通过低剪切混合产生具有不同含量的乳糖细粉的五种乳糖载体的粘合剂混合物，其对应于具有范围从0至6的不同SCR的共混物。用堆密度、压缩性和透气性表征了混合物的粉末力学性能。通过扫描电子显微镜、光学显微镜和原子力显微镜研究了载体和共混物的外观。载体的尺寸和形态对共混状态的演变有至关重要的影响，并影响混合物的粉末力学性能。发现具有很少或没有表面不规则性的较小载体对细粉的添加更敏感，导致细粉在相对低的SCR值下自附聚。相反，具有不规则表面结构和较大尺寸的载体能够在发生细粉自附聚之前达到较高的SCR值。这可能是由于不规则和较大载体的解聚效率增加以及主要粘附在开孔上的细粒。
The aim of this study was to investigate how the carrier morphology affects the expression of blend states in adhesive mixtures as a function of surface coverage ratio (SCR) and to identify where transitions between the different states occur. Adhesive mixtures of five lactose carriers with varying contents of lactose fines, corresponding to blends with different SCR ranging from 0 to 6, were produced by low-shear mixing. The powder mechanics of the mixtures were characterized by bulk density, compressibility and permeability. The appearance of the carriers and blends was studied by scanning electron microscopy, light microscopy and atomic force microscopy. The size and morphology of the carriers had a crucial impact on the evolution of the blend state, and affected the powder mechanical properties of the mixtures. It was found that smaller carriers with little or no surface irregularities were more sensitive to additions of fines resulting in self-agglomeration of fines at relatively low SCR values. On the contrary, carriers with irregular surface structures and larger sizes were able to reach higher SCR values before self-agglomeration of fines occurred. This could be attributed to an increased deagglomeration efficiency of irregular and larger carriers and to fines predominantly adhering to open pores.